{"id":"W4286009256","doi":"10.1139/bcb-2022-0108","title":"Effects of aldo-keto reductase family 1 member A on osteoblast differentiation associated with lactate production in MC3T3-E1 preosteoblastic cells","year":2022,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Aldose Reductase and Taurine","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Osteoblast; NAD+ kinase; Chemistry; Nitric oxide; Cellular differentiation; RUNX2; Nitric oxide synthase; Biochemistry; Cell biology; Biology; Endocrinology; Enzyme","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002185286,0.0003630316,0.0004146012,0.0002083933,0.0002191144,0.0003153782,0.0001679034,0.0002414155,0.0008205563],"category_scores_gemma":[0.0001521103,0.0001568094,0.0004706402,0.0002345425,0.0002099457,0.0001711147,0.0001725233,0.0006269633,0.0002521105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002307079,"about_ca_system_score_gemma":0.0003015263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003042333,"about_ca_topic_score_gemma":0.003306012,"domain_scores_codex":[0.999746,0.00005166028,0.00003761955,0.00003487305,0.00007082974,0.00005903762],"domain_scores_gemma":[0.9998531,0.00003995975,0.00002555264,0.00001652742,0.00003065848,0.00003426293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007513108,0.0001000555,0.0003377581,0.00005817693,0.00001374881,0.0001478919,0.0000560455,0.00005811494,0.997206,0.00005572902,0.000045513,0.001169536],"study_design_scores_gemma":[0.00007622969,0.001215542,0.006676554,0.000006000316,0.00005172964,0.000166766,0.0001076727,0.0006208205,0.9889159,0.00004476613,0.002108884,0.00000896997],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943283,0.003214296,0.0007141497,0.0001229666,0.00007075651,0.00002863627,0.0003502775,0.00003420514,0.001136375],"genre_scores_gemma":[0.9956097,0.001541883,0.0008326804,0.00008750016,0.00001708323,0.00003835146,0.0003879626,0.000008153947,0.001476676],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003042333,"threshold_uncertainty_score":0.006049275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004454341714819704,"score_gpt":0.1959059248721206,"score_spread":0.1914515831573009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}