{"id":"W4286009256","doi":"10.1139/bcb-2022-0108","title":"Effects of aldo-keto reductase family 1 member A on osteoblast differentiation associated with lactate production in MC3T3-E1 preosteoblastic cells","year":2022,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Aldose Reductase and Taurine","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Osteoblast; NAD+ kinase; Chemistry; Nitric oxide; Cellular differentiation; RUNX2; Nitric oxide synthase; Biochemistry; Cell biology; Biology; Endocrinology; Enzyme","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001345428,0.000225783,0.000238065,0.00005843149,0.00009446996,0.000006763698,0.0001132837,0.0001563362,0.00002023168],"category_scores_gemma":[0.00006700896,0.0002034219,0.00004410449,0.0001596652,0.0001277112,0.000004061847,0.0001309274,0.0001839576,0.000001197254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003777615,"about_ca_system_score_gemma":0.00007543433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001472237,"about_ca_topic_score_gemma":0.000004558221,"domain_scores_codex":[0.998673,0.0001611966,0.0002430834,0.0005511389,0.0001078444,0.0002637538],"domain_scores_gemma":[0.9994059,0.00004174915,0.00020611,0.000232074,0.00004954408,0.00006464903],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006625333,0.0005354023,0.0004464347,0.0001372877,0.00006219123,0.000009167913,0.00004896099,0.00006684437,0.9973433,0.000003334138,0.0003401146,0.0003444079],"study_design_scores_gemma":[0.001445798,0.00132544,0.0008230821,0.00003844502,0.00005119923,0.00001155276,0.0001066727,0.00001612536,0.9951947,0.0000159443,0.0007443532,0.0002266504],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981439,0.0007427763,0.000005022996,0.00004770347,0.0001520738,0.0003107853,0.00008336296,0.00001158059,0.0005028709],"genre_scores_gemma":[0.9979101,0.0001575432,0.00001940426,0.00005594097,0.00009019641,0.00009943558,0.0007512967,0.00002096916,0.0008950742],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002148585,"threshold_uncertainty_score":0.8295303,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004454341714819704,"score_gpt":0.1959059248721206,"score_spread":0.1914515831573009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}