{"id":"W4286203086","doi":"10.1227/neu.0000000000002071","title":"Neuropharmacological Study of Posaconazole for Glioblastoma: A Phase 0 Clinical Trial Protocol","year":2022,"lang":"en","type":"article","venue":"Neurosurgery","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Cancer Institute; National Institutes of Health","keywords":"Medicine; Brain tumor; Glycolysis; Glioblastoma; Posaconazole; Oncology; Glioma; Concomitant; Internal medicine; Pharmacology; Cancer research; Pathology; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003041469,0.003086439,0.002960632,0.0006976853,0.001067182,0.001535126,0.001732535,0.002894983,0.02162963],"category_scores_gemma":[0.002442694,0.0009781809,0.001216368,0.0007378261,0.001402068,0.001473112,0.0007362146,0.003880788,0.004433919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00165244,"about_ca_system_score_gemma":0.006090188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001480942,"about_ca_topic_score_gemma":0.004450883,"domain_scores_codex":[0.9988494,0.000507272,0.00006306895,0.0001688181,0.0001218851,0.000289416],"domain_scores_gemma":[0.9982092,0.0001911265,0.0003369148,0.0001719662,0.0002547755,0.0008360389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9055219,0.03839112,0.0009715409,0.001335735,0.0004554012,0.0001787482,0.0001194165,0.001249163,0.008940913,0.0005979231,0.009923421,0.03231479],"study_design_scores_gemma":[0.8132652,0.1732177,0.002520713,0.0001394109,0.0002165148,0.0000912154,0.00004004762,0.0007379966,0.001156424,0.0006472321,0.007932323,0.00003523085],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.444386,0.003084922,0.004895141,0.002730036,0.001107381,0.5145911,0.01320264,0.0007002777,0.01530258],"genre_scores_gemma":[0.358795,0.003757308,0.008223167,0.004073963,0.0005739905,0.6021336,0.006453905,0.00009007117,0.015899],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.02162963,"threshold_uncertainty_score":0.07235831,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06685875925011774,"score_gpt":0.4128063603055502,"score_spread":0.3459476010554324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}