{"id":"W4286213481","doi":"10.3390/cells11142241","title":"Muramyl Dipeptide Administration Delays Alzheimer’s Disease Physiopathology via NOD2 Receptors","year":2022,"lang":"en","type":"article","venue":"Cells","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Wilfrid Laurier University; Université Laval","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Muramyl dipeptide; Microglia; Innate immune system; TREM2; Cognitive decline; Medicine; Population; Receptor; Immunology; Neuroprotection; NOD2; Receptor expression; Immune system; Neuroscience; Inflammation; Dementia; Internal medicine; Biology; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001343355,0.0001772198,0.0001335292,0.0001061305,0.0005806712,0.00005719898,0.0003032456,0.00002656927,0.002038963],"category_scores_gemma":[0.00006476002,0.0001958523,0.00009234553,0.0002912543,0.00005862865,0.0001821342,0.0001481331,0.0002340341,0.0004909234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003015295,"about_ca_system_score_gemma":0.00008569129,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001047391,"about_ca_topic_score_gemma":0.00000134398,"domain_scores_codex":[0.9979898,0.0004560041,0.0003012196,0.0005766269,0.0004060914,0.000270198],"domain_scores_gemma":[0.9991174,0.00009948778,0.0001648309,0.0003927994,0.00002363967,0.000201825],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007653901,0.0001128767,0.000009203587,0.000003713952,0.000001073561,0.0001262834,0.0000774971,0.001363795,0.9913478,0.003057945,0.002771568,0.001051631],"study_design_scores_gemma":[0.0002532992,0.0001839099,0.00007340273,0.000001073321,0.00001943597,0.00003709972,0.00001887448,0.004265025,0.9671196,0.0005881712,0.02723653,0.0002036115],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900354,0.00002780925,0.002250489,0.00184339,0.003324619,0.0006199264,0.00007863918,0.0003494608,0.001470339],"genre_scores_gemma":[0.9938027,0.00001670516,0.0001409972,0.003794277,0.0001213767,0.0001188998,0.00003563108,0.0000364174,0.001932972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02446496,"threshold_uncertainty_score":0.9988733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03547734992324356,"score_gpt":0.2568770788868044,"score_spread":0.2213997289635608,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}