{"id":"W4286213481","doi":"10.3390/cells11142241","title":"Muramyl Dipeptide Administration Delays Alzheimer’s Disease Physiopathology via NOD2 Receptors","year":2022,"lang":"en","type":"article","venue":"Cells","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Wilfrid Laurier University; Université Laval","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Muramyl dipeptide; Microglia; Innate immune system; TREM2; Cognitive decline; Medicine; Population; Receptor; Immunology; Neuroprotection; NOD2; Receptor expression; Immune system; Neuroscience; Inflammation; Dementia; Internal medicine; Biology; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000173492,0.0004044042,0.0003920891,0.0002456064,0.0001075406,0.0002196606,0.0001993049,0.0003394719,0.001848832],"category_scores_gemma":[0.0001538011,0.0001222894,0.0002381022,0.00006516983,0.0002066578,0.0003016965,0.0001785091,0.0005836538,0.0003545847],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001080429,"about_ca_system_score_gemma":0.0002165511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002030828,"about_ca_topic_score_gemma":0.0005215204,"domain_scores_codex":[0.9998621,0.00003475518,0.00001160428,0.00002874252,0.00002461453,0.00003813689],"domain_scores_gemma":[0.9999039,0.000006474345,0.00003332715,0.000008793519,0.0000109732,0.00003640855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004009471,0.0009201521,0.000553143,0.000180927,0.0000340086,0.0001856027,0.00004338684,0.00007475413,0.9811921,0.0002572112,0.000281989,0.01226727],"study_design_scores_gemma":[0.0007769174,0.02434553,0.02295694,0.00008658016,0.0001477732,0.0009326414,0.0001852046,0.001136348,0.9383528,0.000351106,0.01069705,0.00003106404],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926553,0.003297732,0.001256843,0.0002423169,0.0001170001,0.00005526085,0.0002952888,0.0001090507,0.001971228],"genre_scores_gemma":[0.9866061,0.002362047,0.001927253,0.0002143267,0.00008125867,0.0001620868,0.0004051133,0.00002331424,0.00821851],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001848832,"threshold_uncertainty_score":0.006184995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03547734992324356,"score_gpt":0.2568770788868044,"score_spread":0.2213997289635608,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}