{"id":"W4286213922","doi":"10.1101/2022.07.19.500626","title":"Monovalent and trivalent VSV-based COVID-19 vaccines elicit potent neutralizing antibodies and immunodominant CD8+ T cells against diverse SARS-CoV-2 variants","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Public Health Agency; Public Health Agency of Canada","keywords":"Virology; Biology; Neutralizing antibody; Vesicular stomatitis virus; Antibody; Attenuated vaccine; Heterologous; Virus; Immunology; Genetics; Gene; Virulence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002060457,0.0004427284,0.0002279913,0.000203986,0.0001031724,0.000204114,0.0001728187,0.0003269029,0.00157707],"category_scores_gemma":[0.0001234007,0.0001214853,0.0001880332,0.000100619,0.0001700129,0.0002026182,0.0001963999,0.0005465687,0.000420121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003528478,"about_ca_system_score_gemma":0.0001888693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003802202,"about_ca_topic_score_gemma":0.0007506301,"domain_scores_codex":[0.9997697,0.00003671904,0.00001955826,0.00005021249,0.00005795224,0.00006582461],"domain_scores_gemma":[0.9999315,0.00001026823,0.00001660669,0.000008992191,0.00001099858,0.00002179771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002420678,0.0002031545,0.000499457,0.00003065695,0.000009480716,0.00001285905,0.00001302901,0.0001642132,0.9962708,0.0000676018,0.0001066675,0.002380061],"study_design_scores_gemma":[0.0002903309,0.008523699,0.01323922,0.00001717198,0.00006185866,0.0004168638,0.00006912715,0.00199575,0.9697974,0.0001417615,0.005436403,0.00001043925],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972889,0.0003435865,0.0009855463,0.00005494311,0.00003365427,0.00003582869,0.0002004173,0.00003993245,0.001017153],"genre_scores_gemma":[0.9943698,0.0002996869,0.001818924,0.0000922491,0.00001964477,0.00006426626,0.0009804975,0.00001119634,0.002343776],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00157707,"threshold_uncertainty_score":0.005275846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0471808955109787,"score_gpt":0.3102509998838081,"score_spread":0.2630701043728294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}