{"id":"W4286217687","doi":"10.1021/acsomega.2c03473","title":"Synthesis and Biological Evaluation of Arylamide Sulphonate Derivatives as Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 and -3 Inhibitors","year":2022,"lang":"en","type":"article","venue":"ACS Omega","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Higher Education Commission, Pakistan; Deutscher Akademischer Austauschdienst","keywords":"Isozyme; Phosphodiesterase; Chemistry; HeLa; Enzyme; IC50; Docking (animal); Cell culture; Cytotoxicity; Viability assay; Pyrophosphatase; Biochemistry; Pharmacology; In vitro; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008849284,0.00033536,0.0002060807,0.0001560762,0.00009868007,0.0001200034,0.0001725043,0.0001895026,0.001330302],"category_scores_gemma":[0.00006607331,0.00008471986,0.000208006,0.0001713829,0.00008703863,0.000118089,0.00009507659,0.0002615873,0.0002861767],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001340078,"about_ca_system_score_gemma":0.0002070156,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005788198,"about_ca_topic_score_gemma":0.001554031,"domain_scores_codex":[0.9999552,0.000007799679,0.000005161166,0.00000743001,0.00001302198,0.00001145116],"domain_scores_gemma":[0.999974,0.000002864245,0.000006498634,0.000002352355,0.000006924327,0.000007330732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000172869,0.00008801131,0.00006688451,0.0001654442,0.00001156316,0.00012557,0.00001608541,0.0004537175,0.9913119,0.0002347188,0.0001423412,0.007210884],"study_design_scores_gemma":[0.00007144584,0.001593776,0.001086291,0.00001587868,0.00003928249,0.0002580346,0.00001729014,0.000633316,0.9868032,0.00005869973,0.009412209,0.00001051964],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9600894,0.01492072,0.01001694,0.0002006488,0.00012688,0.0002645797,0.001202081,0.0001550441,0.01302354],"genre_scores_gemma":[0.9829187,0.006295573,0.004937721,0.00006623568,0.00001832131,0.00008747279,0.0005716413,0.00001364985,0.005090724],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001330302,"threshold_uncertainty_score":0.004450321,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04874608664601866,"score_gpt":0.3194496159978343,"score_spread":0.2707035293518157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}