{"id":"W4286217687","doi":"10.1021/acsomega.2c03473","title":"Synthesis and Biological Evaluation of Arylamide Sulphonate Derivatives as Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 and -3 Inhibitors","year":2022,"lang":"en","type":"article","venue":"ACS Omega","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Higher Education Commission, Pakistan; Deutscher Akademischer Austauschdienst","keywords":"Isozyme; Phosphodiesterase; Chemistry; HeLa; Enzyme; IC50; Docking (animal); Cell culture; Cytotoxicity; Viability assay; Pyrophosphatase; Biochemistry; Pharmacology; In vitro; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001459329,0.0001647399,0.0003929388,0.0001568516,0.0002636685,0.00001963028,0.00008763023,0.00004068354,0.0001124606],"category_scores_gemma":[0.002952298,0.0001341305,0.00004586517,0.0002865805,0.0004119325,0.0001100593,0.0004724775,0.0001868619,0.000003967732],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000113714,"about_ca_system_score_gemma":0.0001037799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001897757,"about_ca_topic_score_gemma":0.00001270602,"domain_scores_codex":[0.9980115,0.000291635,0.0003089288,0.0003698347,0.0007615953,0.0002564487],"domain_scores_gemma":[0.9986177,0.0007094597,0.0001248216,0.0002306677,0.0002058461,0.0001114793],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00246001,0.0008834293,0.6602854,0.0004392878,0.001094053,0.0002777865,0.0054105,0.00006367682,0.1809641,0.00164425,0.007714254,0.1387632],"study_design_scores_gemma":[0.002453852,0.001388428,0.7038211,0.0001140159,0.000239931,0.0001024785,0.004865088,0.0002290559,0.2813281,0.001661491,0.003504785,0.0002917671],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895999,0.007365779,9.15577e-7,0.001707615,0.00005987259,0.0005885986,0.00005538239,0.00003262474,0.0005892418],"genre_scores_gemma":[0.9975549,0.00170719,0.0001639697,0.0002070934,0.00002773719,0.0002285449,0.00002147112,0.00001850944,0.00007059981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1384714,"threshold_uncertainty_score":0.5469684,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04874608664601866,"score_gpt":0.3194496159978343,"score_spread":0.2707035293518157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}