{"id":"W4286293745","doi":"10.1200/jco.2022.40.16_suppl.12113","title":"Efficacy and safety of SER-109, an investigational microbiome therapeutic for recurrent <i>clostridioides difficile</i> infection: Data from ECOSPOR III, a phase 3 randomized trial.","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Foothills Medical Centre; University of Calgary","funders":"Seres Therapeutics","keywords":"Medicine; Placebo; Internal medicine; Clinical endpoint; Clostridium difficile; Population; Randomized controlled trial; Surgery; Antibiotics; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002227206,0.001117906,0.001871626,0.0002538505,0.0004655717,0.0009082538,0.0006795194,0.001631008,0.005520122],"category_scores_gemma":[0.001874276,0.0004212728,0.001819361,0.000432203,0.0008457893,0.0006914252,0.0002809335,0.0024745,0.0008062065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008163308,"about_ca_system_score_gemma":0.001592752,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002734975,"about_ca_topic_score_gemma":0.00759811,"domain_scores_codex":[0.9992694,0.0004472797,0.0000466495,0.00007613822,0.00005918775,0.0001012011],"domain_scores_gemma":[0.9986375,0.0003558156,0.0004297472,0.00009174032,0.0001126089,0.000372589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.969866,0.003716483,0.00140216,0.000974169,0.001128768,0.00004722387,0.00006167018,0.0002111057,0.001953532,0.00005898004,0.001779402,0.01880037],"study_design_scores_gemma":[0.9090714,0.08010756,0.007586829,0.0001141171,0.001280544,0.00007345963,0.00003833234,0.0002450544,0.0004099594,0.00009379211,0.0009604439,0.00001856699],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9746408,0.01040849,0.0004818278,0.001163941,0.0002515483,0.003666313,0.004521543,0.0001463645,0.004719192],"genre_scores_gemma":[0.9827675,0.005181958,0.001178775,0.001475418,0.0002439407,0.002673715,0.003761425,0.00003105658,0.00268626],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005520122,"threshold_uncertainty_score":0.01846671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2355751553004312,"score_gpt":0.4961658340741805,"score_spread":0.2605906787737493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}