{"id":"W4286293775","doi":"10.1200/jco.2022.40.16_suppl.5057","title":"Impact of activating androgen receptor (AR) mutations on AR sensitivity to alternative ligands and response to ODM-208, a selective, first-in-class CYP11A1 inhibitor, in patients with advanced metastatic castration-resistant prostate cancer (mCRPC).","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Cholesterol side-chain cleavage enzyme; Androgen receptor; CYP17A1; Medicine; Internal medicine; Endocrinology; Androgen; Pregnenolone; Glucocorticoid receptor; Pharmacology; Hormone; Steroid; CYP3A4; Chemistry; Receptor; Prostate cancer; Cytochrome P450; Enzyme; Cancer; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005585156,0.0002296685,0.0004208184,0.0002165019,0.0001584835,0.0004324923,0.0002328595,0.0003645053,0.002315501],"category_scores_gemma":[0.0006438869,0.0001641311,0.000568077,0.0002371581,0.000244688,0.0002298637,0.0001700886,0.0007544704,0.0003287607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005338455,"about_ca_system_score_gemma":0.0004926773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007830309,"about_ca_topic_score_gemma":0.00225925,"domain_scores_codex":[0.9996831,0.00008713504,0.00002765724,0.00007384103,0.00006923651,0.00005898821],"domain_scores_gemma":[0.9996114,0.0001074147,0.00009749943,0.00002397829,0.00002481769,0.0001349276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2233381,0.009245772,0.5023197,0.0005525281,0.001540885,0.001281586,0.0003911907,0.003028474,0.08988968,0.0002458502,0.004945389,0.1632209],"study_design_scores_gemma":[0.007375198,0.09675879,0.873431,0.00004726622,0.001160126,0.001899919,0.0001633534,0.002097668,0.01208699,0.0001653683,0.004765459,0.00004881966],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982844,0.0006665327,0.00003989975,0.00005974071,0.00001291749,0.00004038078,0.0003015624,0.000007134153,0.0005874038],"genre_scores_gemma":[0.9987565,0.0001766881,0.0001119461,0.00007988481,0.00001528093,0.00003013794,0.000517223,0.000003415543,0.0003090035],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002315501,"threshold_uncertainty_score":0.0077461,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05253178606062217,"score_gpt":0.4454671328024595,"score_spread":0.3929353467418374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}