{"id":"W4286294073","doi":"10.1200/jco.2022.40.16_suppl.tps5110","title":"CCTG PR21: A randomized phase II study of [<sup>177</sup>lu]lu-PSMA-617 verus docetaxel in patients with metastatic castration-resistant prostate cancer and PSMA-positive disease (NCT04663997).","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lions Gate Hospital; McMaster University; Western University; Juravinski Cancer Centre; BC Cancer Agency; Princess Margaret Cancer Centre; Université Laval; Université de Montréal; University of British Columbia","funders":"","keywords":"Medicine; Docetaxel; Prostate cancer; Tolerability; Taxane; Response Evaluation Criteria in Solid Tumors; Internal medicine; Oncology; Adverse effect; Progression-free survival; Chemotherapy; Population; Progressive disease; Cancer; Urology; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002417165,0.002618544,0.002852862,0.0006573382,0.0008459795,0.001348725,0.001787457,0.003194168,0.01182201],"category_scores_gemma":[0.001753902,0.001102844,0.001702112,0.0009473924,0.001394037,0.0009168033,0.0005067129,0.004128085,0.002478347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003028514,"about_ca_system_score_gemma":0.006907347,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01771552,"about_ca_topic_score_gemma":0.05386579,"domain_scores_codex":[0.9990957,0.0004036718,0.00003934118,0.0001242482,0.0001214225,0.0002157075],"domain_scores_gemma":[0.9988105,0.0001453091,0.0002492571,0.00007147862,0.00009521121,0.0006282694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9297103,0.02460668,0.001362691,0.0009544008,0.001025537,0.0001529649,0.000140836,0.0006163538,0.007958838,0.0001926263,0.005077355,0.02820142],"study_design_scores_gemma":[0.9233732,0.07232227,0.002154086,0.00001983594,0.0002507376,0.00006219361,0.00002075849,0.000178732,0.0002446908,0.00006853182,0.001291232,0.00001379137],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.953889,0.005276311,0.0006598393,0.00176095,0.0007441625,0.0258925,0.004264505,0.0003253918,0.007187412],"genre_scores_gemma":[0.9525566,0.004286234,0.002497417,0.003680714,0.0007496682,0.0181758,0.006490421,0.0001080935,0.011455],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01771552,"threshold_uncertainty_score":0.03954858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.068962979691834,"score_gpt":0.4587294802030558,"score_spread":0.3897665005112217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}