{"id":"W4286294367","doi":"10.1200/jco.2022.40.16_suppl.tps12144","title":"The RADIO trial: Randomized assessment of cisplatin dosing interval for ototoxicity with curative concurrent chemo-radiation for locally advanced head and neck squamous cell carcinoma.","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Ear and Head Tumors","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juravinski Cancer Centre; Sunnybrook Health Science Centre; Western University; Ontario Clinical Oncology Group; Cancer Care Ontario; McMaster University; London Health Sciences Centre","funders":"Academic Medical Organization of Southwestern Ontario","keywords":"Medicine; Ototoxicity; Tolerability; Head and neck squamous-cell carcinoma; Oncology; Cisplatin; Randomized controlled trial; Internal medicine; Quality of life (healthcare); Hazard ratio; Head and neck cancer; Hearing loss; Radiation therapy; Adverse effect; Confidence interval; Chemotherapy; Audiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006482244,0.0001215586,0.001826431,0.00005849248,0.0001532113,0.000008798709,0.0001017055,0.00009022754,0.00001481732],"category_scores_gemma":[0.003024242,0.00006989072,0.0005049465,0.00006743049,0.000253392,0.00006076501,0.00003630137,0.000661819,5.804943e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002111088,"about_ca_system_score_gemma":0.001735738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006705957,"about_ca_topic_score_gemma":0.00002121543,"domain_scores_codex":[0.9965037,0.0007312809,0.002125663,0.0001607088,0.0002967959,0.0001818782],"domain_scores_gemma":[0.9840745,0.0126916,0.00256571,0.0001020181,0.0004066975,0.0001594409],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9534061,0.001370915,0.004874173,0.0001127497,0.0001781353,0.00002008642,0.0003928237,0.0002111762,0.0002547521,0.0004706294,0.0006612755,0.03804719],"study_design_scores_gemma":[0.8873063,0.07738259,0.01481188,0.00005940387,0.0006322315,0.00008735634,0.0005518207,0.01224592,0.000432563,0.0002523523,0.006146132,0.00009147202],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9795034,0.0005549444,0.01210035,0.003558869,0.0009914793,0.003032403,0.00001427403,0.000003852916,0.0002404385],"genre_scores_gemma":[0.9924348,0.00007832165,0.006443973,0.0004200711,0.0003816298,0.0001521942,0.000006740855,0.00001512048,0.00006714447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07601168,"threshold_uncertainty_score":0.3620519,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07987995410677115,"score_gpt":0.469365463369902,"score_spread":0.3894855092631309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}