{"id":"W4286295232","doi":"10.1200/jco.2022.40.16_suppl.2589","title":"The effect of circadian rhythm on clinical outcome in patients receiving pembrolizumab in the INSPIRE pan-cancer trial.","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"Princess Margaret Cancer Foundation","keywords":"Pembrolizumab; Medicine; Cohort; Internal medicine; Oncology; Melanoma; Adverse effect; Cancer; Immunotherapy; Breast cancer; Immune system; Immunology; Cancer research","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002477355,0.0002702637,0.0005869041,0.0001552976,0.0001713431,0.0004010731,0.0003626079,0.0003475164,0.001056224],"category_scores_gemma":[0.00217734,0.0001425671,0.0007890328,0.0002038849,0.0001667038,0.0004332444,0.0002871657,0.0006943286,0.00009838166],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000453158,"about_ca_system_score_gemma":0.0003934767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008365039,"about_ca_topic_score_gemma":0.002325145,"domain_scores_codex":[0.9994992,0.0002402224,0.00003475767,0.0001141951,0.00005671706,0.00005490263],"domain_scores_gemma":[0.999182,0.0001806946,0.0004001338,0.00007374182,0.00004318014,0.0001201677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.5087723,0.001520413,0.3367442,0.001219512,0.00480902,0.0001470949,0.0001227029,0.002842729,0.009456696,0.0003542909,0.006736512,0.1272746],"study_design_scores_gemma":[0.02817185,0.03212963,0.9274311,0.0001307524,0.002855472,0.0002922885,0.00004963801,0.004071547,0.001050944,0.0002757805,0.003504574,0.00003631006],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925531,0.004520485,0.0001903621,0.0002350346,0.00004900138,0.0001321361,0.001025717,0.00001926652,0.001274908],"genre_scores_gemma":[0.997624,0.0004198819,0.0001952967,0.0001604565,0.00004460939,0.0001248646,0.001143244,0.000004772991,0.0002828816],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002477355,"threshold_uncertainty_score":0.01310164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1164887187995321,"score_gpt":0.489061600304296,"score_spread":0.3725728815047639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}