{"id":"W4286295491","doi":"10.1200/jco.2022.40.16_suppl.4136","title":"Phase Ib study of anetumab ravtansive in combination with immunotherapy or immunotherapy plus chemotherapy in mesothelin-enriched advanced pancreatic adenocarcinoma: NCI10208.","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Princess Margaret Cancer Centre","funders":"National Institutes of Health","keywords":"Nivolumab; Medicine; Mesothelin; Gemcitabine; Internal medicine; Oncology; Pancreatic cancer; Immunotherapy; Ipilimumab; Tolerability; Deoxycytidine; Gastroenterology; Cancer; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00124617,0.001665076,0.002139401,0.0006465329,0.0004667346,0.001129863,0.001291377,0.0014644,0.003944275],"category_scores_gemma":[0.0005092429,0.0006859472,0.001288597,0.0005712125,0.0007477218,0.0007208483,0.0004751264,0.003139112,0.001345675],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001129337,"about_ca_system_score_gemma":0.001763105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001815861,"about_ca_topic_score_gemma":0.004527542,"domain_scores_codex":[0.9996132,0.0001435433,0.00002167734,0.00007868585,0.00004176547,0.0001012052],"domain_scores_gemma":[0.9996433,0.00003723635,0.00006131945,0.00005012323,0.00002717129,0.0001807924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5129519,0.2213909,0.006573411,0.001761138,0.001760797,0.0004502344,0.0004251342,0.004853294,0.1068317,0.0003753371,0.006931718,0.1356945],"study_design_scores_gemma":[0.2364167,0.7396546,0.00927647,0.00006204422,0.0005136835,0.0004107415,0.00008471111,0.001291927,0.007441824,0.0001581507,0.004651717,0.00003737285],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900633,0.001690318,0.0004423617,0.0002969191,0.0001519265,0.003209535,0.001813023,0.0001939389,0.002138837],"genre_scores_gemma":[0.9796046,0.002302022,0.002077633,0.0007443292,0.0001449816,0.004914694,0.005186,0.00004990044,0.004975826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003944275,"threshold_uncertainty_score":0.01319492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09108027032456575,"score_gpt":0.4738530316721102,"score_spread":0.3827727613475445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}