{"id":"W4286296187","doi":"10.1200/jco.2022.40.16_suppl.5056","title":"Activation of the AKT pathway and outcomes in patients (pts) treated with or without ipatasertib (ipat) in metastatic castration-resistant prostate cancer (mCRPC): Next-generation sequencing (NGS) data from the phase III IPATential150 trial.","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"PTEN; Medicine; Prostate cancer; Internal medicine; Clinical endpoint; Cancer; Prednisone; Placebo; Oncology; Interim analysis; Gastroenterology; Pathology; Randomized controlled trial; PI3K/AKT/mTOR pathway","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009872406,0.0004034477,0.0007253637,0.0002078684,0.0001795025,0.000470339,0.0003082534,0.0004834378,0.00208676],"category_scores_gemma":[0.0009498781,0.0002211263,0.001304159,0.0004026412,0.0003373142,0.0003652255,0.0003431277,0.001131297,0.0002260368],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005074965,"about_ca_system_score_gemma":0.0005824646,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007729679,"about_ca_topic_score_gemma":0.001736924,"domain_scores_codex":[0.9997013,0.0001298303,0.00002409866,0.00006262035,0.00003873699,0.00004336947],"domain_scores_gemma":[0.99946,0.000111249,0.0002303868,0.00003538933,0.00002050411,0.0001423523],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.7968164,0.003494477,0.1302678,0.0008422974,0.00461097,0.0001690419,0.0001082578,0.002528609,0.005826467,0.0002231438,0.002686239,0.05242632],"study_design_scores_gemma":[0.2111876,0.1988848,0.5650882,0.0002282188,0.009412863,0.0007758103,0.0001480249,0.004084644,0.003598747,0.00107827,0.005441478,0.00007138057],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949461,0.002286205,0.0002293425,0.0001563903,0.00003988943,0.0001705838,0.001422998,0.00001525151,0.0007333952],"genre_scores_gemma":[0.9969288,0.0007085593,0.0002048296,0.0001325172,0.0000579102,0.0002212793,0.001328232,0.000003350478,0.0004147011],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00208676,"threshold_uncertainty_score":0.006980896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.400716399784368,"score_gpt":0.4940344414384111,"score_spread":0.09331804165404317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}