{"id":"W4286297269","doi":"10.1200/jco.2022.40.16_suppl.4553","title":"Preventing adverse events in patients with renal cell carcinoma treated with doublet immunotherapy using fecal microbiota transplantation (FMT): Initial results from perform a phase I study.","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; London Health Sciences Centre; St Joseph's Health Care; Western University","funders":"","keywords":"Medicine; Renal cell carcinoma; Clinical endpoint; Adverse effect; Immunotherapy; Internal medicine; Oncology; Immune system; Transplantation; Cancer; Gastroenterology; Immunology; Surgery; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001839838,0.0008948799,0.001685571,0.000291359,0.0004220582,0.0005805787,0.0004323751,0.000794429,0.001452572],"category_scores_gemma":[0.00108764,0.0002919145,0.001703537,0.0003145303,0.0005314767,0.0004653947,0.0003243508,0.001401372,0.0002662729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007315375,"about_ca_system_score_gemma":0.001444992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007093303,"about_ca_topic_score_gemma":0.001601302,"domain_scores_codex":[0.9995033,0.0002422423,0.00003126803,0.00007389734,0.00005286597,0.00009645901],"domain_scores_gemma":[0.9988593,0.0002421684,0.0002391944,0.0001092963,0.00007263204,0.0004773846],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5444254,0.174666,0.04199281,0.001475762,0.003355541,0.0005078482,0.0005576981,0.003382242,0.04640193,0.0001565,0.00220895,0.1808694],"study_design_scores_gemma":[0.09667202,0.8546381,0.0431253,0.00004671396,0.000669177,0.0002787904,0.00006700368,0.000621583,0.002741564,0.00005628646,0.001064711,0.00001884127],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969289,0.001233659,0.000278174,0.0001045666,0.00002207912,0.0006580816,0.0002923532,0.00001986954,0.0004623166],"genre_scores_gemma":[0.994949,0.001083071,0.001213907,0.0004276352,0.00013257,0.0008994989,0.0008437533,0.000009510537,0.0004409481],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001839838,"threshold_uncertainty_score":0.009730101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04305914038949379,"score_gpt":0.3847621146993261,"score_spread":0.3417029743098323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}