{"id":"W4286298026","doi":"10.1200/jco.2022.40.16_suppl.1015","title":"Quality of life (QOL) with ribociclib (RIB) plus aromatase inhibitor (AI) versus abemaciclib (ABE) plus AI as first-line (1L) treatment (tx) of hormone receptor-positive/human epidermal growth factor receptor–negative (HR+/HER2−) advanced breast cancer (ABC), assessed via matching-adjusted indirect comparison (MAIC).","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Novartis (Canada)","funders":"","keywords":"Medicine; Quality of life (healthcare); Internal medicine; Oncology; Aromatase inhibitor; Letrozole; Progression-free survival; Cancer; Breast cancer; Aromatase; Overall survival","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002548556,0.0006081641,0.001294535,0.0004333939,0.0001428238,0.0007985945,0.0004470902,0.0005609313,0.004822327],"category_scores_gemma":[0.00315953,0.0001697571,0.003399697,0.0004866853,0.000399998,0.0007495636,0.000600232,0.001777058,0.0003593884],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008813282,"about_ca_system_score_gemma":0.0005706145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007538397,"about_ca_topic_score_gemma":0.00134096,"domain_scores_codex":[0.9985271,0.0009199207,0.0001154575,0.0001355772,0.0001480449,0.0001538249],"domain_scores_gemma":[0.9984754,0.0005927923,0.0005192503,0.00006013493,0.00007315506,0.0002792386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8736234,0.003735758,0.0202071,0.002106105,0.01183687,0.00004244588,0.0001056391,0.002336635,0.001626498,0.0003947932,0.00186063,0.08212399],"study_design_scores_gemma":[0.217144,0.5599558,0.1826542,0.0006580789,0.02130247,0.0002967807,0.0003042151,0.006611484,0.002693699,0.001774133,0.006479972,0.0001251328],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984004,0.01011043,0.0003160358,0.0004098542,0.0002254128,0.0003706434,0.002065559,0.00002140183,0.002476686],"genre_scores_gemma":[0.996107,0.001220303,0.0003273574,0.0001730529,0.00008004844,0.0003856499,0.001099828,0.000004929674,0.0006017915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004822327,"threshold_uncertainty_score":0.01613224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1017267633768129,"score_gpt":0.4531026573683878,"score_spread":0.3513758939915749,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}