{"id":"W4286298149","doi":"10.1200/jco.2022.40.16_suppl.4564","title":"Prognostic impact of bone metastasis in patients with metastatic urothelial carcinoma (mUC) treated with durvalumab (D) with or without tremelimumab (T) in the DANUBE study.","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Durvalumab; Internal medicine; Metastatic Urothelial Carcinoma; Oncology; Post-hoc analysis; Chemotherapy; Gastroenterology; Cisplatin; Proportional hazards model; Cancer; Immunotherapy; Urothelial carcinoma; Bladder cancer; Nivolumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009343174,0.0002866029,0.0004749647,0.0003198043,0.0002471749,0.0006302512,0.0005366683,0.0004414885,0.0007860954],"category_scores_gemma":[0.001148045,0.0001759357,0.0005772031,0.000380006,0.0002438182,0.0003438542,0.000550803,0.0005608124,0.00009898627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005582388,"about_ca_system_score_gemma":0.0003902733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002765575,"about_ca_topic_score_gemma":0.007153158,"domain_scores_codex":[0.9996418,0.0001440392,0.00002847286,0.00007428223,0.00006283694,0.00004858965],"domain_scores_gemma":[0.9993618,0.0001412569,0.000242218,0.00003774443,0.00003072542,0.0001862847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007944383,0.00009805522,0.9835982,0.00005100304,0.000406628,0.0001993393,0.00002942827,0.0002163232,0.001254565,0.00003368405,0.0004130288,0.005755314],"study_design_scores_gemma":[0.0004578084,0.001035067,0.9961609,0.00001716887,0.0002612223,0.0004373708,0.00006404165,0.0007128938,0.0002213536,0.00003580857,0.0005891318,0.000007273898],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981868,0.001138827,0.00002677919,0.00007658656,0.000008563641,0.00001002236,0.0002891722,0.000001733167,0.000261521],"genre_scores_gemma":[0.9991078,0.0001721307,0.00003770037,0.00004344537,0.00001500315,0.00001030201,0.0004877027,0.00000105075,0.0001249708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002765575,"threshold_uncertainty_score":0.005499005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09915499778419397,"score_gpt":0.4290532779881926,"score_spread":0.3298982802039986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}