{"id":"W4286298185","doi":"10.1200/jco.2022.40.16_suppl.tps4614","title":"A phase 3 study of the subcutaneous programmed cell death protein 1 inhibitor sasanlimab as single agent for patients with bacillus Calmette-Guérin, unresponsiv,e high-risk, non-muscle invasive bladder cancer: CREST Study Cohort B.","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Pfizer","keywords":"Medicine; Bladder cancer; Pembrolizumab; Cystectomy; Internal medicine; Cohort; Carcinoma in situ; Oncology; Urology; Concomitant; Cancer; Surgery; Gastroenterology; Immunotherapy","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002169712,0.002026027,0.002018173,0.0003710928,0.0006269066,0.001389996,0.001111955,0.001642723,0.003464615],"category_scores_gemma":[0.001354774,0.0007740053,0.002418467,0.0003714961,0.001096032,0.0009380704,0.0005502659,0.003586428,0.001202491],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001293417,"about_ca_system_score_gemma":0.002946758,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002997715,"about_ca_topic_score_gemma":0.005964011,"domain_scores_codex":[0.9993569,0.0002515919,0.00003043062,0.0001249731,0.00007525906,0.0001608438],"domain_scores_gemma":[0.9985042,0.0001148942,0.0002303307,0.0001399834,0.0001364636,0.0008742505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8278236,0.07811686,0.01455923,0.0006681664,0.002388986,0.0003600031,0.0003219181,0.001434959,0.03172402,0.0002304192,0.005614742,0.03675711],"study_design_scores_gemma":[0.656156,0.3164717,0.02068856,0.00002824108,0.0008802197,0.0002969375,0.00008502105,0.001045559,0.001675994,0.0001633215,0.002462454,0.00004601082],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895316,0.0009700443,0.0005024436,0.0004610035,0.0001357679,0.004495094,0.002422111,0.00007858715,0.00140335],"genre_scores_gemma":[0.9781966,0.001230846,0.002721916,0.001924791,0.0002751109,0.006355946,0.006675384,0.00005608996,0.002563447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003464615,"threshold_uncertainty_score":0.0115903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05761441077137525,"score_gpt":0.3880984322002823,"score_spread":0.330484021428907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}