{"id":"W4286355229","doi":"10.1016/bs.pmbts.2022.06.010","title":"Molecular and cellular mechanisms underlying brain region-specific endocannabinoid system modulation by estradiol across the rodent estrus cycle","year":2022,"lang":"en","type":"review","venue":"Progress in molecular biology and translational science","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University; University of Saskatchewan","funders":"","keywords":"Endocannabinoid system; Cannabinoid receptor; Estrous cycle; Forebrain; Internal medicine; Cannabinoid; Endocrinology; Neuroscience; Biology; Periaqueductal gray; Estrogen; Agonist; Receptor; Midbrain; Medicine; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003140605,0.0006393931,0.0009767844,0.00110012,0.0001785397,0.0008083258,0.0006752289,0.0006534608,0.002823187],"category_scores_gemma":[0.0003488849,0.0002019256,0.0002439293,0.001424054,0.0004019708,0.0007845496,0.0005125905,0.001079961,0.001298568],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006616013,"about_ca_system_score_gemma":0.001055198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001678273,"about_ca_topic_score_gemma":0.003801513,"domain_scores_codex":[0.9999369,0.000007719234,0.000009144359,0.00001642236,0.0000201911,0.000009583508],"domain_scores_gemma":[0.9998945,0.00004221933,0.0000183751,0.000003749466,0.0000281303,0.00001298312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002141453,0.00005282009,0.0002630329,0.01207829,0.0001082243,0.0002839414,0.00005022063,0.0005870432,0.009708437,0.005163777,0.01316349,0.9583266],"study_design_scores_gemma":[0.00003771273,0.0001185369,0.00265912,0.00242541,0.0002134421,0.001032111,0.0001047068,0.0001452605,0.002295007,0.004231655,0.9867003,0.0000367117],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000221312,0.9985003,0.0001434673,0.0001815327,0.00008183562,0.00000327747,0.00002966483,0.000004985345,0.0008335397],"genre_scores_gemma":[0.0009429087,0.9982533,0.0001342922,0.00008742196,0.00006073054,0.000003952179,0.0000304183,6.399607e-7,0.0004864162],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002823187,"threshold_uncertainty_score":0.009444475,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03697475759367251,"score_gpt":0.3659722276715791,"score_spread":0.3289974700779066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}