{"id":"W4286434176","doi":"10.3390/cells11142259","title":"Functional Expression of Multidrug-Resistance (MDR) Transporters in Developing Human Fetal Brain Endothelial Cells","year":2022,"lang":"en","type":"article","venue":"Cells","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Mount Sinai Hospital; Sinai Health System; Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"Fundação de Amparo à Pesquisa do Estado de Minas Gerais; Canadian Institutes of Health Research; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Abcg2; Biology; Immunostaining; P-glycoprotein; Blood–brain barrier; Multidrug resistance-associated protein 2; Cell biology; Multiple drug resistance; ATP-binding cassette transporter; Endocrinology; Molecular biology; Immunology; Transporter; Drug resistance; Biochemistry; Immunohistochemistry; Central nervous system; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001365324,0.00009467237,0.0001457668,0.0002845594,0.0001386925,0.0002655385,0.0001142903,0.0001632821,0.001289345],"category_scores_gemma":[0.0002379974,0.0000949973,0.0001100341,0.000169062,0.0001128995,0.0001784648,0.0001242566,0.0002958654,0.0003124269],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002448845,"about_ca_system_score_gemma":0.0001560033,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003803336,"about_ca_topic_score_gemma":0.002024685,"domain_scores_codex":[0.9999125,0.000013406,0.000009185039,0.00001701855,0.00002787896,0.00002002032],"domain_scores_gemma":[0.9998624,0.00003727098,0.00002043368,0.00001395804,0.00004170074,0.00002420553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001669496,0.00002290359,0.001586269,0.00006258929,0.000008467647,0.0003457056,0.000159244,0.00004394376,0.9932504,0.0003148317,0.0001036699,0.003935117],"study_design_scores_gemma":[0.0000343273,0.0006916601,0.1273209,0.00005470086,0.00007650815,0.003502844,0.000527903,0.001757228,0.8489221,0.0003934314,0.01668921,0.00002914659],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884622,0.004921408,0.003369988,0.00006684002,0.0000200259,0.00002712969,0.001117145,0.00005614379,0.001959147],"genre_scores_gemma":[0.9879546,0.003022659,0.003754982,0.00005780895,0.00001376107,0.00005781248,0.00219052,0.00001603259,0.00293171],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003803336,"threshold_uncertainty_score":0.007562399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01549709700936257,"score_gpt":0.2331688636018021,"score_spread":0.2176717665924396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}