{"id":"W4286434176","doi":"10.3390/cells11142259","title":"Functional Expression of Multidrug-Resistance (MDR) Transporters in Developing Human Fetal Brain Endothelial Cells","year":2022,"lang":"en","type":"article","venue":"Cells","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Mount Sinai Hospital; Sinai Health System; Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"Fundação de Amparo à Pesquisa do Estado de Minas Gerais; Canadian Institutes of Health Research; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Abcg2; Biology; Immunostaining; P-glycoprotein; Blood–brain barrier; Multidrug resistance-associated protein 2; Cell biology; Multiple drug resistance; ATP-binding cassette transporter; Endocrinology; Molecular biology; Immunology; Transporter; Drug resistance; Biochemistry; Immunohistochemistry; Central nervous system; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002957358,0.0001827621,0.0003592328,0.0001926431,0.0001599751,0.000004477757,0.0001347841,0.0000636625,0.0007088996],"category_scores_gemma":[0.000002590265,0.0001770754,0.0001662417,0.0002480398,0.0000724819,0.00005635856,0.00002090247,0.0002793451,0.000007332399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001286762,"about_ca_system_score_gemma":0.0001409926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002474701,"about_ca_topic_score_gemma":0.00008984964,"domain_scores_codex":[0.9983039,0.00005236386,0.0004827253,0.0003479719,0.0005133075,0.0002996781],"domain_scores_gemma":[0.9994832,0.00004672322,0.0001305382,0.0002207015,0.00003374113,0.00008503984],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004474244,0.0002138101,0.0006404032,0.0002201669,0.0000143845,0.0001490404,0.0008682783,0.0003422539,0.9954585,0.0002833271,0.001249465,0.0001129175],"study_design_scores_gemma":[0.002981728,0.00006471462,0.003418921,0.0001924791,0.00002705176,0.000003134288,0.0007900737,0.00002547234,0.9778665,0.0001146158,0.0143133,0.0002020324],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925346,0.0001472552,0.003657464,0.0004362967,0.0007355065,0.0004745142,0.0001339991,0.00004682046,0.001833526],"genre_scores_gemma":[0.9873537,0.00001584132,0.002405484,0.0002976684,0.00009009555,0.00004848281,0.000135091,0.00003537964,0.009618288],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01759205,"threshold_uncertainty_score":0.7761954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01549709700936257,"score_gpt":0.2331688636018021,"score_spread":0.2176717665924396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}