{"id":"W4286437560","doi":"10.1200/jco.2022.40.17_suppl.lba7502","title":"Primary results from the double-blind, placebo-controlled, phase III SHINE study of ibrutinib in combination with bendamustine-rituximab (BR) and R maintenance as a first-line treatment for older patients with mantle cell lymphoma (MCL).","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Medicine; Clinical endpoint; Internal medicine; Neutropenia; Bendamustine; Phases of clinical research; Placebo; Ibrutinib; Chemoimmunotherapy; Rituximab; Surgery; Population; Hazard ratio; Gastroenterology; Chemotherapy; Randomized controlled trial; Confidence interval; Leukemia; Lymphoma; Chronic lymphocytic leukemia; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003268059,0.0002338479,0.001991211,0.0001633754,0.0001363745,0.00001361499,0.000254017,0.0001399631,0.00004764077],"category_scores_gemma":[0.0009473416,0.0001211201,0.0001789919,0.0002596971,0.0002225295,0.00009520156,0.0001449875,0.0005146428,9.490804e-7],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.004103345,"about_ca_system_score_gemma":0.00750645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001090541,"about_ca_topic_score_gemma":0.0009181765,"domain_scores_codex":[0.9953917,0.0004891561,0.002500476,0.0004000842,0.0008814421,0.0003371321],"domain_scores_gemma":[0.9891035,0.007568791,0.002194952,0.0003617679,0.0005782036,0.0001928017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9013886,0.06637237,0.006904038,0.00003940439,0.0006922664,0.0005243011,0.001573868,0.0002855935,0.000005159125,0.00001329644,0.0004639428,0.02173713],"study_design_scores_gemma":[0.8386011,0.1386151,0.01552945,0.0001164971,0.0007127945,0.0001193628,0.001238958,0.002256095,0.00001995817,0.0000388821,0.002647523,0.0001042812],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915659,0.0002254642,0.00004081921,0.002990901,0.0001879121,0.004510669,0.00007680606,0.000005889003,0.0003956005],"genre_scores_gemma":[0.9981112,0.0001262279,0.0004684164,0.000405398,0.0001647118,0.0002350582,0.00008471121,0.00003036239,0.0003738542],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0722427,"threshold_uncertainty_score":0.9997197,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07259979377230029,"score_gpt":0.4085435094493707,"score_spread":0.3359437156770704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}