{"id":"W4286437560","doi":"10.1200/jco.2022.40.17_suppl.lba7502","title":"Primary results from the double-blind, placebo-controlled, phase III SHINE study of ibrutinib in combination with bendamustine-rituximab (BR) and R maintenance as a first-line treatment for older patients with mantle cell lymphoma (MCL).","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Medicine; Clinical endpoint; Internal medicine; Neutropenia; Bendamustine; Phases of clinical research; Placebo; Ibrutinib; Chemoimmunotherapy; Rituximab; Surgery; Population; Hazard ratio; Gastroenterology; Chemotherapy; Randomized controlled trial; Confidence interval; Leukemia; Lymphoma; Chronic lymphocytic leukemia; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003792239,0.002523938,0.003630596,0.0004815329,0.0006587957,0.001353313,0.001177542,0.002046457,0.00866696],"category_scores_gemma":[0.002425335,0.001121966,0.002112492,0.0004652579,0.001458426,0.001074369,0.0004294356,0.003160106,0.001449583],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007742082,"about_ca_system_score_gemma":0.001424114,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008041709,"about_ca_topic_score_gemma":0.002401354,"domain_scores_codex":[0.9992504,0.0003980681,0.00005678746,0.0001398085,0.00005338348,0.0001015551],"domain_scores_gemma":[0.998513,0.0003733444,0.000400028,0.000106991,0.0001407968,0.0004656995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9800255,0.007169574,0.0005172457,0.0008369864,0.001083266,0.00002675977,0.00004325219,0.0001884958,0.002821263,0.00004277936,0.0009871746,0.006257781],"study_design_scores_gemma":[0.9520732,0.04447935,0.001731834,0.00003333715,0.0006181158,0.00002118218,0.00001213046,0.0001171041,0.0003171005,0.00005468155,0.0005331124,0.000008945762],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9558998,0.01063993,0.001472352,0.001231195,0.0009129312,0.01785448,0.006032125,0.0003385271,0.005618609],"genre_scores_gemma":[0.9717278,0.004129291,0.00217267,0.00191634,0.0005759384,0.01077779,0.003087892,0.00006393161,0.005548318],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00866696,"threshold_uncertainty_score":0.0289939,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07259979377230029,"score_gpt":0.4085435094493707,"score_spread":0.3359437156770704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}