{"id":"W4286449069","doi":"10.1016/j.cell.2022.06.046","title":"Synthetic chromosomes, genomes, viruses, and cells","year":2022,"lang":"en","type":"review","venue":"Cell","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":126,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"International Development Research Centre; National Institute of Allergy and Infectious Diseases; J. Craig Venter Institute; National Institutes of Health; National Science Foundation","keywords":"Biology; Genome; Synthetic biology; Genetics; Genomics; Nucleic acid; Computational biology; DNA; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000413553,0.0008742299,0.0008803164,0.001717019,0.0003177659,0.00121397,0.0008585557,0.001075603,0.003663065],"category_scores_gemma":[0.0004139042,0.0003522156,0.0003446226,0.001577464,0.000817874,0.001408277,0.0008842027,0.001784627,0.003178907],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008140225,"about_ca_system_score_gemma":0.0007488193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008792601,"about_ca_topic_score_gemma":0.001117205,"domain_scores_codex":[0.9997787,0.00003026581,0.00001635153,0.00004322838,0.0001092729,0.00002225966],"domain_scores_gemma":[0.9998866,0.00005338268,0.00001557157,0.000007015466,0.00002199215,0.00001534162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005930504,0.00008007597,0.0001053716,0.01312474,0.0000373794,0.0002692385,0.0001226334,0.001024341,0.0120385,0.05989046,0.0433065,0.8699415],"study_design_scores_gemma":[0.000003543123,0.0000207659,0.00005695708,0.0003915299,0.000006427617,0.0002347452,0.00001301414,0.00003330833,0.001375619,0.002834586,0.9950227,0.000006915096],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002760232,0.9905338,0.001418433,0.0002779616,0.0004105342,0.00001360877,0.00004471435,0.00003406629,0.00699095],"genre_scores_gemma":[0.002274469,0.9914768,0.001130005,0.0003125283,0.0001791209,0.00003022726,0.0001181769,0.00001199274,0.004466582],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003663065,"threshold_uncertainty_score":0.01225418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01871756493060957,"score_gpt":0.2983897260159045,"score_spread":0.279672161085295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}