{"id":"W4286449069","doi":"10.1016/j.cell.2022.06.046","title":"Synthetic chromosomes, genomes, viruses, and cells","year":2022,"lang":"en","type":"review","venue":"Cell","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":126,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"International Development Research Centre; National Institute of Allergy and Infectious Diseases; J. Craig Venter Institute; National Institutes of Health; National Science Foundation","keywords":"Biology; Genome; Synthetic biology; Genetics; Genomics; Nucleic acid; Computational biology; DNA; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001062981,0.000321851,0.0005236022,0.00006137939,0.00006885693,0.00002517782,0.0002481849,0.0002077965,0.00029653],"category_scores_gemma":[0.00000775121,0.0003106253,0.0002093105,0.00008090326,0.00003737285,7.24064e-7,0.0003131298,0.0002001199,0.00003569771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002293041,"about_ca_system_score_gemma":0.0001310476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003898256,"about_ca_topic_score_gemma":0.000001686204,"domain_scores_codex":[0.9988381,0.00005408269,0.0002498411,0.0005092504,0.00009492011,0.0002538054],"domain_scores_gemma":[0.9992784,0.00002296571,0.00008574952,0.0005034967,0.000007011422,0.0001023639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000002992615,0.00006345726,7.695887e-7,0.01103178,0.0001240428,0.00003018499,0.0000252788,0.00002517249,0.00927515,0.000007124317,0.004870759,0.9745433],"study_design_scores_gemma":[0.00008208703,0.00007232479,1.44108e-7,0.0001545446,0.0001923711,0.00004477141,0.000007028807,0.00000207931,0.004331799,0.000002095945,0.9947633,0.0003474107],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003032087,0.9970037,0.00009527445,0.000001381562,0.0003260775,0.0002858637,0.00008505853,0.00001514817,0.002157185],"genre_scores_gemma":[0.00003051535,0.9970815,0.000222188,0.00003628789,0.0002252014,0.00007151427,0.000223598,0.00008361274,0.002025644],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9898926,"threshold_uncertainty_score":0.9999346,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01871756493060957,"score_gpt":0.2983897260159045,"score_spread":0.279672161085295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}