{"id":"W4286487914","doi":"10.3389/fimmu.2022.864868","title":"Programmable Attenuation of Antigenic Sensitivity for a Nanobody-Based EGFR Chimeric Antigen Receptor Through Hinge Domain Truncation","year":2022,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; National Research Council Canada; Institute of Infection and Immunity; University of Ottawa","funders":"National Research Council Canada","keywords":"Epitope; Jurkat cells; Antigen; Chimeric antigen receptor; Cancer research; Epidermal growth factor receptor; Molecular biology; Biology; Chemistry; Receptor; Cell biology; Immunotherapy; Immunology; T cell; Immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001199867,0.0001591244,0.0005201772,0.0003647365,0.0001754432,0.000007857724,0.0001396124,0.0001228377,0.0003683236],"category_scores_gemma":[0.0001381135,0.0001744821,0.0001657237,0.0007754122,0.0002375662,0.00008652014,0.00007220845,0.0003504656,0.0000038526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005733648,"about_ca_system_score_gemma":0.0003925968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003088961,"about_ca_topic_score_gemma":0.00001935059,"domain_scores_codex":[0.9979466,0.0005042818,0.0004019614,0.0003826956,0.0003032236,0.0004612769],"domain_scores_gemma":[0.9990618,0.0001197001,0.0002164305,0.0004360443,0.0001365549,0.00002944292],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.005220118,0.0006734118,0.04770266,0.0001224048,0.0003282805,0.00001232445,0.001721675,0.0001472906,0.8803342,0.0001627294,0.003444218,0.06013072],"study_design_scores_gemma":[0.03004689,0.00874575,0.08253319,0.0001833646,0.0002001487,0.0001370463,0.00899193,0.01508056,0.3409816,0.004354234,0.5077076,0.001037691],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9496984,0.001947467,0.04301916,0.001533788,0.001152497,0.002325223,0.00004820237,0.00005938155,0.0002158222],"genre_scores_gemma":[0.9033956,0.0003054187,0.09310257,0.0002218751,0.0000961,0.0007987478,0.0008116208,0.00007051296,0.001197579],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5393525,"threshold_uncertainty_score":0.7115174,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0204181923470274,"score_gpt":0.2925643669610613,"score_spread":0.2721461746140338,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}