{"id":"W4286492057","doi":"10.1089/crispr.2021.0132","title":"Allele-Specific Inactivation of an Autosomal Dominant Epidermolysis Bullosa Simplex Mutation Using CRISPR-Cas9","year":2022,"lang":"en","type":"article","venue":"The CRISPR Journal","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval; Centre Hospitalier Universitaire Sainte-Justine; Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; Université Laval; Université du Québec à Chicoutimi","funders":"","keywords":"Epidermolysis bullosa simplex; Keratin 5; Keratin 14; Biology; CRISPR; Mutant; Genetics; Keratin; Epidermolysis bullosa; Cas9; Allele; Gene; Molecular biology; Transgene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000708134,0.0001510227,0.0001754099,0.00009812874,0.0005002376,0.00003874961,0.0002901759,0.00005502205,0.000180346],"category_scores_gemma":[0.00005509452,0.000127158,0.0001386281,0.0001636036,0.00005110056,0.00001261874,0.0001331823,0.0002781911,9.819565e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000603162,"about_ca_system_score_gemma":0.00007548894,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003227522,"about_ca_topic_score_gemma":0.000004116326,"domain_scores_codex":[0.9986065,0.0002417029,0.0003964502,0.0002076024,0.0002948125,0.0002529071],"domain_scores_gemma":[0.9992119,0.00002630165,0.0002474128,0.0003206072,0.0001148454,0.0000789406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001503573,0.00007568544,0.00004157762,0.000008461181,0.00006437061,0.00004339889,0.0004471992,0.06145819,0.9307225,0.0000533509,0.0005412273,0.00639373],"study_design_scores_gemma":[0.0009363588,0.0005123119,0.001591674,0.000008821189,0.0000871113,0.004469086,0.003126957,0.0163781,0.9596127,0.0003940896,0.0126092,0.0002736456],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8892239,0.0009155988,0.1092127,0.0002288599,0.0002261461,0.0001222923,0.00001364652,0.000006383944,0.00005048392],"genre_scores_gemma":[0.9972565,0.0001162757,0.002036601,0.00005338955,0.0004070486,0.000009418455,0.00004979098,0.00002962634,0.00004136393],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1080326,"threshold_uncertainty_score":0.5185351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02021961584689575,"score_gpt":0.3168270845139955,"score_spread":0.2966074686670997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}