{"id":"W4286492057","doi":"10.1089/crispr.2021.0132","title":"Allele-Specific Inactivation of an Autosomal Dominant Epidermolysis Bullosa Simplex Mutation Using CRISPR-Cas9","year":2022,"lang":"en","type":"article","venue":"The CRISPR Journal","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval; Centre Hospitalier Universitaire Sainte-Justine; Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; Université Laval; Université du Québec à Chicoutimi","funders":"","keywords":"Epidermolysis bullosa simplex; Keratin 5; Keratin 14; Biology; CRISPR; Mutant; Genetics; Keratin; Epidermolysis bullosa; Cas9; Allele; Gene; Molecular biology; Transgene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001652748,0.0003446,0.0002712459,0.0001932904,0.0001319651,0.0002490928,0.0002901066,0.0003450434,0.001416194],"category_scores_gemma":[0.0001650072,0.0001544175,0.0003427001,0.0001049082,0.0001918715,0.0001115294,0.0003204333,0.0004065818,0.000468318],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002094309,"about_ca_system_score_gemma":0.0001978738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005369733,"about_ca_topic_score_gemma":0.0008391596,"domain_scores_codex":[0.9997531,0.00002953269,0.00003875759,0.00006379742,0.00009056924,0.00002426079],"domain_scores_gemma":[0.9999192,0.00001927368,0.00002485072,0.00001562698,0.00000607653,0.00001506353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004467678,0.00001849262,0.0002609494,0.0000571179,0.00001470176,0.00035898,0.00002589017,0.0001625338,0.9951893,0.0002973044,0.00008147455,0.0034885],"study_design_scores_gemma":[0.00002242077,0.0001418078,0.002342769,0.00001396989,0.00003958076,0.002027913,0.00002931778,0.00266289,0.9852888,0.00009923091,0.00731796,0.00001329899],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9486766,0.001297586,0.04234992,0.0001312683,0.0001376835,0.0001932467,0.001184333,0.001003946,0.005025369],"genre_scores_gemma":[0.9770774,0.0005871046,0.01776973,0.00005112251,0.00000655673,0.00007942763,0.0005404807,0.00009133959,0.003796804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001416194,"threshold_uncertainty_score":0.004737675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02021961584689575,"score_gpt":0.3168270845139955,"score_spread":0.2966074686670997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}