{"id":"W4286499046","doi":"10.1101/2022.07.20.500840","title":"Actively replicating gut bacteria identified by 5-ethynyl-2’-deoxyuridine (EdU) click chemistry and cell sorting","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"McGill University Health Centre; Kenneth Rainin Foundation; McGill University","keywords":"Bacteria; Biology; Cell sorting; Click chemistry; Gut flora; Bacterial cell structure; Microbial metabolism; Microbiology; Cell; Genetics; Biochemistry; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000551185,0.0004863706,0.0003614451,0.0005804484,0.0002789574,0.000497969,0.00027834,0.0006355131,0.001550879],"category_scores_gemma":[0.0003930089,0.0002591276,0.0002999956,0.0003445392,0.0003652417,0.0002832348,0.000472728,0.0006708429,0.0009711329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002297594,"about_ca_system_score_gemma":0.0001940532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000463635,"about_ca_topic_score_gemma":0.001013667,"domain_scores_codex":[0.9996617,0.00004597555,0.00002217016,0.0000806946,0.0001269951,0.00006246327],"domain_scores_gemma":[0.9996448,0.0001034065,0.0000768307,0.00004391887,0.00008643706,0.000044611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001654586,0.000005432574,0.0002112674,0.00002678192,0.000001863089,0.00001704801,0.00001181557,0.00004412722,0.9984021,0.00005832347,0.00004004585,0.001164578],"study_design_scores_gemma":[0.000002360332,0.00006495781,0.002041328,0.000008015166,0.000005116691,0.00007238632,0.00001975244,0.001715765,0.9941784,0.00004886067,0.001836409,0.000006619305],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8567893,0.00168698,0.1333718,0.0002648774,0.0001377191,0.0002458829,0.001931612,0.001586207,0.003985597],"genre_scores_gemma":[0.8529234,0.001874843,0.1328163,0.0003461601,0.00003407422,0.0003852811,0.003239069,0.0003436471,0.008037338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001550879,"threshold_uncertainty_score":0.005188227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008956801514285715,"score_gpt":0.2317870106827371,"score_spread":0.2228302091684514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}