{"id":"W4286500719","doi":"10.1093/toxsci/kfac076","title":"Gestational and Lactational Exposure to the Emergent Alternative Plasticizer 1,2-Cyclohexane Dicarboxylic Acid Diisononyl Ester (DINCH) Impairs Lipid Metabolism to a Greater Extent Than the Commonly Used Di(2-Ethylhexyl) Phthalate (DEHP) in the Adult Rat Mammary Gland","year":2022,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Effects and risks of endocrine disrupting chemicals","field":"Environmental Science","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université du Québec à Montréal; Institut National de la Recherche Scientifique","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Phthalate; Endocrinology; Internal medicine; Lipid metabolism; Chemistry; Fatty acid; Lipid droplet; Endocrine system; Mammary gland; Biology; Hormone; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001083759,0.0004185079,0.0002162701,0.0003036333,0.0001316451,0.0002265281,0.0001466609,0.0002576487,0.001586521],"category_scores_gemma":[0.0001172922,0.0001907071,0.0003184826,0.0001695541,0.0002922759,0.0001928791,0.000216255,0.0005999929,0.0001581639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000328202,"about_ca_system_score_gemma":0.000402929,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001625632,"about_ca_topic_score_gemma":0.003417828,"domain_scores_codex":[0.9998052,0.00002205818,0.00001711924,0.00006361623,0.00004451441,0.00004757765],"domain_scores_gemma":[0.9998251,0.00001892061,0.00006959131,0.00002203637,0.0000180656,0.00004631896],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007172584,0.00009314908,0.001001539,0.00003391508,0.000009648941,0.00008564535,0.00002773228,0.00002365988,0.9961355,0.0000470668,0.00002862065,0.001796338],"study_design_scores_gemma":[0.00002237385,0.002639564,0.03567369,0.00001126949,0.00005377397,0.0003092876,0.0001592415,0.0002142827,0.9588261,0.00006220567,0.002018303,0.000009997228],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972897,0.0009483406,0.0008071719,0.00009308978,0.0000344116,0.00001365554,0.0003300716,0.00003023013,0.0004534498],"genre_scores_gemma":[0.9912553,0.001699082,0.001124488,0.000124812,0.00001447826,0.0000682973,0.0005724083,0.00001636345,0.005124794],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001625632,"threshold_uncertainty_score":0.005307436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0203557998183172,"score_gpt":0.3068368010676845,"score_spread":0.2864810012493673,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}