{"id":"W4286511695","doi":"10.1016/s0140-6736(22)01193-x","title":"Intervention with methotrexate in patients with arthralgia at risk of rheumatoid arthritis to reduce the development of persistent arthritis and its disease burden (TREAT EARLIER): a randomised, double-blind, placebo-controlled, proof-of-concept trial","year":2022,"lang":"en","type":"article","venue":"The Lancet","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":173,"is_retracted":false,"has_abstract":false,"ca_institutions":"Arthritis Society","funders":"Leids Universitair Medisch Centrum; Erasmus Medisch Centrum; ZonMw; Arthritis Society; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Dutch Arthritis Society; Haaglanden Medisch Centrum","keywords":"Medicine; Rheumatoid arthritis; Placebo; Arthritis; Internal medicine; Clinical endpoint; Rheumatology; Physical therapy; Methotrexate; Clinical trial; Subclinical infection; Randomized controlled trial; Surgery; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001546343,0.0002251086,0.001121894,0.0001582007,0.0002428892,0.00002126627,0.0002423406,0.0000279641,0.000170591],"category_scores_gemma":[0.0001786131,0.0001208728,0.0002060182,0.0002745109,0.0002215257,0.00008480041,0.0001919879,0.0002757203,0.000001227946],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007282888,"about_ca_system_score_gemma":0.0001638405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009302067,"about_ca_topic_score_gemma":0.0002617097,"domain_scores_codex":[0.9970927,0.0007074308,0.0007471738,0.0003029518,0.0007984579,0.000351337],"domain_scores_gemma":[0.9985183,0.0002611917,0.0004615473,0.0004294547,0.0001732068,0.0001563031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9402252,0.0004489821,0.005367354,0.00007560601,0.0006973434,0.000007773248,0.008051717,0.0007151238,0.00005698411,0.0000253561,0.00008660143,0.04424199],"study_design_scores_gemma":[0.9835241,0.003890286,0.004880332,0.00181972,0.00004578867,0.00001556805,0.001652593,0.0001504334,0.003467068,0.00002989207,0.0003461545,0.0001780577],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.976597,0.01557981,0.00002279278,0.0007608911,0.00004528548,0.00677112,0.0001160804,0.00001228157,0.00009475339],"genre_scores_gemma":[0.9952177,0.002794812,0.0002007909,0.00001541957,0.00003322085,0.001534266,0.00004765542,0.00002646118,0.0001297034],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04406394,"threshold_uncertainty_score":0.4929051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02267469314465283,"score_gpt":0.2721832574457261,"score_spread":0.2495085643010733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}