{"id":"W4286511695","doi":"10.1016/s0140-6736(22)01193-x","title":"Intervention with methotrexate in patients with arthralgia at risk of rheumatoid arthritis to reduce the development of persistent arthritis and its disease burden (TREAT EARLIER): a randomised, double-blind, placebo-controlled, proof-of-concept trial","year":2022,"lang":"en","type":"article","venue":"The Lancet","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":173,"is_retracted":false,"has_abstract":false,"ca_institutions":"Arthritis Society","funders":"Leids Universitair Medisch Centrum; Erasmus Medisch Centrum; ZonMw; Arthritis Society; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Dutch Arthritis Society; Haaglanden Medisch Centrum","keywords":"Medicine; Rheumatoid arthritis; Placebo; Arthritis; Internal medicine; Clinical endpoint; Rheumatology; Physical therapy; Methotrexate; Clinical trial; Subclinical infection; Randomized controlled trial; Surgery; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002150811,0.001974744,0.004976755,0.0005908287,0.0005596947,0.00134896,0.0009903399,0.004095104,0.00844698],"category_scores_gemma":[0.002720137,0.0007337962,0.00408558,0.0004563701,0.0010834,0.001008973,0.0005532459,0.003482054,0.001109162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005819821,"about_ca_system_score_gemma":0.0008692469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001505554,"about_ca_topic_score_gemma":0.0022624,"domain_scores_codex":[0.9988856,0.0005754512,0.0001008465,0.0001933697,0.0001017627,0.0001429858],"domain_scores_gemma":[0.9988919,0.0005189716,0.0002695501,0.00006414672,0.00007125208,0.0001842537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9756479,0.002543955,0.0002663029,0.003079375,0.002408353,0.00004595783,0.00005215731,0.000151679,0.001562674,0.000143831,0.0006182626,0.01347956],"study_design_scores_gemma":[0.9765003,0.02110511,0.0006774383,0.0001234677,0.0008582877,0.00002402572,0.00001350733,0.00008536677,0.0001115276,0.00009581317,0.000396523,0.000008683013],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8828438,0.08545846,0.002588122,0.003212091,0.006601227,0.01016174,0.002053911,0.0003870004,0.006693611],"genre_scores_gemma":[0.9467782,0.02605823,0.004657083,0.003918164,0.003277092,0.008196978,0.00118723,0.0000390167,0.00588795],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00844698,"threshold_uncertainty_score":0.02825803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02267469314465283,"score_gpt":0.2721832574457261,"score_spread":0.2495085643010733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}