{"id":"W4286511893","doi":"10.1038/s41419-022-05059-2","title":"SMOC2 promotes an epithelial-mesenchymal transition and a pro-metastatic phenotype in epithelial cells of renal cell carcinoma origin","year":2022,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Natural Sciences and Engineering Research Council of Canada; Kidney Foundation of Canada; Canadian Society of Nephrology; Government of Canada; Fondation de l’Hôpital Maisonneuve-Rosemont; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Epithelial–mesenchymal transition; Extracellular matrix; Renal cell carcinoma; Mesenchymal stem cell; Metastasis; Cell biology; Cancer; Cancer cell; Cancer research; Cell; Pathology; Biology; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001184795,0.0002359891,0.0002287988,0.0002077492,0.0001802867,0.0001588908,0.0001042596,0.0001601827,0.001046549],"category_scores_gemma":[0.00005523109,0.0001219945,0.0002596618,0.0001393294,0.000133415,0.00008045121,0.0001341981,0.0005108546,0.0002654238],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001799043,"about_ca_system_score_gemma":0.0002340514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001374153,"about_ca_topic_score_gemma":0.002221973,"domain_scores_codex":[0.9998848,0.00001359374,0.000009242585,0.00001481371,0.00004225412,0.00003523878],"domain_scores_gemma":[0.9999441,0.000006067601,0.000009110555,0.000006867027,0.00000943929,0.00002451644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005841785,0.00003522339,0.0001907952,0.00002154882,0.0000036128,0.00004502104,0.00001007606,0.00002784755,0.9990939,0.00005717834,0.0000530554,0.0004033888],"study_design_scores_gemma":[0.00001653032,0.0004212948,0.01144733,0.000003536377,0.00001433024,0.0002783884,0.00003734266,0.001187715,0.9843129,0.00002692915,0.002250464,0.000003271278],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960872,0.0008089068,0.001044106,0.00008131135,0.00002795347,0.00002460419,0.0003344329,0.00005869246,0.001532901],"genre_scores_gemma":[0.9947022,0.0004598841,0.0008184954,0.0000467996,0.000007288553,0.00003060614,0.0006462673,0.000008236532,0.003280204],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001374153,"threshold_uncertainty_score":0.003500998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01959544265919031,"score_gpt":0.2525107821407227,"score_spread":0.2329153394815324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}