{"id":"W4286511893","doi":"10.1038/s41419-022-05059-2","title":"SMOC2 promotes an epithelial-mesenchymal transition and a pro-metastatic phenotype in epithelial cells of renal cell carcinoma origin","year":2022,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Natural Sciences and Engineering Research Council of Canada; Kidney Foundation of Canada; Canadian Society of Nephrology; Government of Canada; Fondation de l’Hôpital Maisonneuve-Rosemont; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Epithelial–mesenchymal transition; Extracellular matrix; Renal cell carcinoma; Mesenchymal stem cell; Metastasis; Cell biology; Cancer; Cancer cell; Cancer research; Cell; Pathology; Biology; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002377939,0.0001985237,0.0003516821,0.0001720829,0.0001026483,0.00001726315,0.00006009232,0.00002607549,0.0002617694],"category_scores_gemma":[0.00001335101,0.0001810413,0.00008206776,0.0001933079,0.00008111716,0.00008854546,0.00004385786,0.0001737753,0.000002147525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004571783,"about_ca_system_score_gemma":0.0004088439,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004190701,"about_ca_topic_score_gemma":0.00001580758,"domain_scores_codex":[0.9985812,0.0001335412,0.0003006442,0.0004152342,0.0002809614,0.000288362],"domain_scores_gemma":[0.998989,0.00003461949,0.00009025289,0.0002328132,0.00004058701,0.0006127135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008795016,0.005125662,0.02878074,0.004877428,0.00005261606,0.001556045,0.007506727,0.0003839654,0.9225702,0.0002858579,0.0003023789,0.01976336],"study_design_scores_gemma":[0.05969878,0.01342279,0.1884231,0.0003642399,0.005420168,0.0001664627,0.006668233,0.01889902,0.6820076,0.006546701,0.01565893,0.00272399],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952981,0.002491696,0.0001101947,0.0001516104,0.00008886906,0.0007772873,0.000670799,0.00001688822,0.0003945876],"genre_scores_gemma":[0.998424,0.0001344353,0.0006312511,0.0002243877,0.00007620203,0.00007900747,0.0001319549,0.0000267561,0.0002720129],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2405626,"threshold_uncertainty_score":0.7382649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01959544265919031,"score_gpt":0.2525107821407227,"score_spread":0.2329153394815324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}