{"id":"W4286512182","doi":"10.1016/j.cbi.2022.110049","title":"Down-regulation of hepatic cytochromes P450 1A1 and 1A2 by arsenic trioxide (ATO) in vivo and in vitro: A role of heme oxygenase 1","year":2022,"lang":"en","type":"article","venue":"Chemico-Biological Interactions","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"HMOX1; Arsenic trioxide; Heme oxygenase; In vivo; CYP1A2; Chemistry; Heme; Cytochrome P450; GCLC; In vitro; Pharmacology; Toxicity; Biochemistry; Enzyme; Molecular biology; Glutathione; Biology; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002668552,0.0004060467,0.0002865233,0.0003103062,0.0002330505,0.0003290297,0.0001811809,0.0002404293,0.001544187],"category_scores_gemma":[0.0002801012,0.0001963483,0.0002795447,0.0002140626,0.0002767161,0.0002606316,0.000142816,0.0004443761,0.0003284145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003793493,"about_ca_system_score_gemma":0.0002313319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001251657,"about_ca_topic_score_gemma":0.001748955,"domain_scores_codex":[0.9998337,0.00005846539,0.00001615637,0.0000235818,0.00003187247,0.00003618919],"domain_scores_gemma":[0.9997852,0.00006640622,0.0000458287,0.00003098419,0.00003053913,0.00004098503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006735331,0.00005388856,0.0003203156,0.0000265039,0.00001044572,0.00006904294,0.00001934261,0.00007217663,0.9972001,0.0001378705,0.00008143381,0.001335297],"study_design_scores_gemma":[0.0000261909,0.0002706639,0.003262235,0.000002021988,0.00001751432,0.0001816654,0.00003482009,0.0005286532,0.9946378,0.00006694686,0.0009672609,0.000004108509],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927067,0.002684921,0.002549445,0.0003732712,0.00009450491,0.00002426686,0.000283074,0.0001038243,0.00117997],"genre_scores_gemma":[0.9944735,0.0009258921,0.001171088,0.00005350138,0.00003032214,0.0000168543,0.0003841726,0.00002066338,0.002923914],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001544187,"threshold_uncertainty_score":0.005165815,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007649194844540975,"score_gpt":0.2383368244018995,"score_spread":0.2306876295573586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}