{"id":"W4286512182","doi":"10.1016/j.cbi.2022.110049","title":"Down-regulation of hepatic cytochromes P450 1A1 and 1A2 by arsenic trioxide (ATO) in vivo and in vitro: A role of heme oxygenase 1","year":2022,"lang":"en","type":"article","venue":"Chemico-Biological Interactions","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"HMOX1; Arsenic trioxide; Heme oxygenase; In vivo; CYP1A2; Chemistry; Heme; Cytochrome P450; GCLC; In vitro; Pharmacology; Toxicity; Biochemistry; Enzyme; Molecular biology; Glutathione; Biology; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001304617,0.0001240325,0.0002314261,0.00006788867,0.00004010655,0.000006113441,0.0001063435,0.00009897128,0.0001421904],"category_scores_gemma":[0.0001326937,0.0001134146,0.00005404123,0.0001436564,0.0001418936,0.000008351572,0.0001671887,0.0001713321,3.263146e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003912683,"about_ca_system_score_gemma":0.00003225488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005467759,"about_ca_topic_score_gemma":0.00001318093,"domain_scores_codex":[0.9990692,0.00007110341,0.0003502046,0.0002945566,0.00006937067,0.0001455733],"domain_scores_gemma":[0.9995653,0.00007129476,0.0001480666,0.0001449115,0.00003144981,0.00003896689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002541966,0.0001572549,0.003856097,0.00003154116,0.0000169393,9.256332e-7,0.00008600071,0.00002485682,0.9950331,0.00001540374,0.0001517611,0.0003719243],"study_design_scores_gemma":[0.0005226681,0.0001434891,0.002133443,0.0000155185,0.000008615891,0.00003478115,0.0005481754,0.0002830476,0.9932842,0.000284567,0.002623156,0.0001183797],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971581,0.002097664,0.00002724625,0.00004551884,0.00002770992,0.0001536217,0.00007641438,0.000005315883,0.000408448],"genre_scores_gemma":[0.999035,0.0003594117,0.0001608085,0.00004312851,0.00002048317,0.00008206765,0.0001334382,0.000007772916,0.0001579026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002471395,"threshold_uncertainty_score":0.4624914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007649194844540975,"score_gpt":0.2383368244018995,"score_spread":0.2306876295573586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}