{"id":"W4286516488","doi":"10.1136/bmjopen-2021-053039","title":"Low-dose trimethoprim-sulfamethoxazole for the treatment of <i>Pneumocystis jirovecii</i> pneumonia (LOW-TMP): protocol for a phase III randomised, placebo-controlled, dose-comparison trial","year":2022,"lang":"en","type":"article","venue":"BMJ Open","topic":"Pneumocystis jirovecii pneumonia detection and treatment","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; St. Michael's Hospital; Jewish General Hospital; Ottawa Hospital; University Health Network; Centre Hospitalier Universitaire de Sherbrooke; University of British Columbia; University of Manitoba; University of Calgary; McGill University Health Centre; McGill University; Sinai Health System","funders":"McGill University","keywords":"Medicine; Trimethoprim; Placebo; Pneumocystis jirovecii; Sulfamethoxazole; Internal medicine; Pneumonia; Clinical trial; Adverse effect; Observational study; Surgery; Antibiotics; Alternative medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02141214,0.006938161,0.01039072,0.00144663,0.00249769,0.004163964,0.003833258,0.006096952,0.05461239],"category_scores_gemma":[0.01790476,0.002822682,0.006003581,0.002281688,0.003534089,0.003142676,0.001428957,0.006557213,0.01036069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005111141,"about_ca_system_score_gemma":0.01254211,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002624085,"about_ca_topic_score_gemma":0.007058359,"domain_scores_codex":[0.9890777,0.006419854,0.001069471,0.001202474,0.001129545,0.001101002],"domain_scores_gemma":[0.9921566,0.001340658,0.002419811,0.0009381798,0.001777707,0.00136711],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9361105,0.004281007,0.0005181161,0.0248753,0.003071912,0.000127121,0.0002126999,0.0007361248,0.001996092,0.001485599,0.01487518,0.01171036],"study_design_scores_gemma":[0.9675472,0.01070935,0.001381782,0.002410475,0.001496367,0.00004762794,0.00005335582,0.0006737277,0.0004461744,0.001125921,0.01404683,0.00006128089],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.004601684,0.001351617,0.00128739,0.0005165931,0.0006667387,0.9868225,0.002988332,0.0001711785,0.001594004],"genre_scores_gemma":[0.006716453,0.0005904515,0.002136681,0.0004827192,0.0001001737,0.9882783,0.0007435889,0.00001596137,0.0009356486],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.05461239,"threshold_uncertainty_score":0.1826967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09758552553586426,"score_gpt":0.4556079999180704,"score_spread":0.3580224743822062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}