{"id":"W4286559780","doi":"10.21203/rs.3.rs-1871890/v1","title":"Functional discovery of targetable dependencies in recurrent glioblastoma","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juravinski Hospital; National Research Council Canada; Princess Margaret Cancer Centre; University of Toronto; McMaster University","funders":"Mitacs; Terry Fox Research Institute","keywords":"Glioblastoma; Computer science; Computational biology; Cancer research; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000160568,0.0002601614,0.000317649,0.0003273686,0.00009035041,0.0003585705,0.0002078877,0.0002502481,0.001595863],"category_scores_gemma":[0.0002178641,0.0001601651,0.0002497018,0.0001654277,0.0001561553,0.0001328239,0.0002839803,0.0003757732,0.0002866406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000328355,"about_ca_system_score_gemma":0.0001905199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007822154,"about_ca_topic_score_gemma":0.001150436,"domain_scores_codex":[0.9998381,0.00001222802,0.0000105356,0.00004189392,0.00006918341,0.00002816888],"domain_scores_gemma":[0.999885,0.00001818121,0.00004734219,0.00001567097,0.00001580063,0.00001795298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005350232,0.000009204649,0.0005865924,0.00002674753,0.000009716505,0.00006957108,0.000005673384,0.0001416383,0.9971303,0.0001097521,0.00003959227,0.001817635],"study_design_scores_gemma":[0.0000123239,0.0001827096,0.01230444,0.000003893535,0.00004652334,0.0007492413,0.00001663022,0.002631836,0.9811633,0.0001473577,0.002734795,0.000006942055],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890056,0.0007513706,0.007235163,0.0001009477,0.00002072254,0.00003053426,0.001265488,0.0003081308,0.001281991],"genre_scores_gemma":[0.9954368,0.0002634619,0.002258699,0.00003559888,0.000003813618,0.00001640912,0.0007863101,0.00003276209,0.001166176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001595863,"threshold_uncertainty_score":0.005338669,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07355946433401077,"score_gpt":0.3829308605643093,"score_spread":0.3093713962302985,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}