{"id":"W4286559954","doi":"10.1038/s41467-022-31906-z","title":"Modulating co-translational protein folding by rational design and ribosome engineering","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Interdyscyplinarne Centrum Modelowania Matematycznego i Komputerowego UW; Biotechnology and Biological Sciences Research Council; Medical Research Council; Uniwersytet Warszawski; Wellcome; University of Birmingham; Wellcome Trust; Francis Crick Institute; Cancer Research UK","keywords":"Ribosome; Protein folding; Folding (DSP implementation); Protein engineering; Rational design; Computational biology; Posttranslational modification; Translation (biology); Cell biology; Protein biosynthesis; Protein design; Chemistry; Protein structure; Computer science; Biology; Biochemistry; RNA; Genetics; Messenger RNA; Engineering; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000540859,0.0004957204,0.0005271816,0.0002573755,0.0002086044,0.0006108938,0.000529946,0.0004478359,0.0008989525],"category_scores_gemma":[0.0006340828,0.0002450039,0.0003029428,0.0003047478,0.000439577,0.0004104128,0.0004259678,0.0007910286,0.0004613604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006373576,"about_ca_system_score_gemma":0.0003402546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002665495,"about_ca_topic_score_gemma":0.0006564364,"domain_scores_codex":[0.9996754,0.000075964,0.00002999826,0.00006750093,0.00009056488,0.00006060908],"domain_scores_gemma":[0.9997867,0.00006052537,0.00007310047,0.00003228389,0.00002431317,0.00002310233],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000199326,0.0002037007,0.0003495121,0.0001871023,0.0000293037,0.0001509481,0.00004160473,0.01769217,0.9669111,0.005138878,0.0001940481,0.008902277],"study_design_scores_gemma":[0.00006890066,0.0006004956,0.0004625364,0.00002635647,0.00003925429,0.0001665599,0.00004280784,0.04153018,0.9479826,0.001087143,0.007964517,0.00002860553],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9300913,0.001899126,0.06227768,0.0004562144,0.00008651034,0.0002243071,0.0001852115,0.0004096821,0.004370041],"genre_scores_gemma":[0.9679709,0.001134143,0.02950386,0.00006262068,0.00001101533,0.000117501,0.0001028073,0.00007622335,0.001020969],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008989525,"threshold_uncertainty_score":0.004624367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01493820492698106,"score_gpt":0.260394531466136,"score_spread":0.2454563265391549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}