{"id":"W4286560817","doi":"10.21203/rs.3.rs-1834770/v1","title":"Early-to-mid idiopathic Parkinson’s disease shows a more cytotoxic but declined CD8-regulatory peripheral immune profile","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"International Council for Canadian Studies; RIKEN; Fonds National de la Recherche Luxembourg; Integrated BioBank of Luxembourg","keywords":"Cytotoxic T cell; Immune system; Peripheral; CD8; Disease; Parkinson's disease; Immunology; Medicine; Neuroscience; Biology; Genetics; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009609564,0.0002469014,0.0002361376,0.0004634809,0.0002052435,0.000274936,0.00005678534,0.0001785595,0.002446962],"category_scores_gemma":[0.0001552695,0.00007411306,0.0001185714,0.0001577418,0.0001707827,0.0001212121,0.000197083,0.0002008835,0.0003479427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007344691,"about_ca_system_score_gemma":0.00004128367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001810576,"about_ca_topic_score_gemma":0.0001608647,"domain_scores_codex":[0.9999468,0.000007012483,0.000006235176,0.00001901557,0.00000812914,0.00001280866],"domain_scores_gemma":[0.999915,0.00001441727,0.0000210467,0.000009210131,0.00001417977,0.00002612093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00446497,0.0002540952,0.328384,0.000190896,0.00007409431,0.003181663,0.000629367,0.0001239702,0.6327441,0.0001334589,0.0003973253,0.02942204],"study_design_scores_gemma":[0.00005626957,0.001083668,0.948442,0.00001862475,0.00005364203,0.008893834,0.0003231202,0.000339814,0.038592,0.00024742,0.00193994,0.000009633863],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987651,0.0004241014,0.0002057035,0.00001186094,0.000004864739,0.000005341913,0.0001396074,0.000008681297,0.0004347829],"genre_scores_gemma":[0.9992071,0.00008435602,0.0001229239,0.00001308109,0.000006609958,0.000004781669,0.0001976044,0.000002143383,0.0003615191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002446962,"threshold_uncertainty_score":0.008185863,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03971181911109928,"score_gpt":0.3295231067711947,"score_spread":0.2898112876600955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}