{"id":"W4286560817","doi":"10.21203/rs.3.rs-1834770/v1","title":"Early-to-mid idiopathic Parkinson’s disease shows a more cytotoxic but declined CD8-regulatory peripheral immune profile","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"International Council for Canadian Studies; RIKEN; Fonds National de la Recherche Luxembourg; Integrated BioBank of Luxembourg","keywords":"Cytotoxic T cell; Immune system; Peripheral; CD8; Disease; Parkinson's disease; Immunology; Medicine; Neuroscience; Biology; Genetics; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","research_integrity","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.00342652,0.0009426192,0.001328243,0.000971246,0.001761815,0.0003469864,0.00227375,0.001200606,0.005075947],"category_scores_gemma":[0.001250232,0.0009355869,0.0007832502,0.0007906688,0.0009143121,0.0002788843,0.005520454,0.006350697,0.001731539],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001174232,"about_ca_system_score_gemma":0.003661157,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008503455,"about_ca_topic_score_gemma":0.00008389376,"domain_scores_codex":[0.9898898,0.00344174,0.001113516,0.002203669,0.0008614505,0.00248985],"domain_scores_gemma":[0.9950178,0.0002988953,0.0002966863,0.003013287,0.000867185,0.0005061384],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01240786,0.003370841,0.03330053,0.007971112,0.001835023,0.002282165,0.01901717,0.0007539968,0.8807026,0.001014832,0.02474597,0.01259788],"study_design_scores_gemma":[0.005787286,0.003072934,0.4764494,0.004498064,0.0002585569,0.000109401,0.01151926,0.0001541296,0.05978519,0.001275719,0.4333251,0.003765028],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9473526,0.03016871,0.00003949098,0.0006632282,0.002747751,0.004272934,0.01370184,0.0004320202,0.0006214488],"genre_scores_gemma":[0.9691435,0.001374324,0.00007795774,0.0001857334,0.0005483495,0.00457461,0.00323263,0.0002194201,0.02064354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8209174,"threshold_uncertainty_score":0.9995378,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03971181911109928,"score_gpt":0.3295231067711947,"score_spread":0.2898112876600955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}