{"id":"W4286587073","doi":"10.1101/2022.07.20.500862","title":"Pre-Germinal Center Interactions with T Cells are Natural Checkpoints to Limit Autoimmune B Cell Responses","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Multiple Sclerosis Society; Natural Sciences and Engineering Research Council of Canada; Multiple Sclerosis Society of Canada","keywords":"Germinal center; CD40; Antigen; B cell; Cell biology; B-cell receptor; Biology; Antigen-presenting cell; Cytotoxic T cell; T cell; Immunology; Antibody; Immune system; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002035381,0.0003538526,0.0002504299,0.0002688468,0.0002876091,0.0006752142,0.0002916477,0.0005090965,0.004680396],"category_scores_gemma":[0.0002270055,0.0002028722,0.0001718125,0.0001225155,0.0002461451,0.0004004917,0.0004139667,0.0008424039,0.002766239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000288418,"about_ca_system_score_gemma":0.0002428373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001722119,"about_ca_topic_score_gemma":0.0003508202,"domain_scores_codex":[0.9998295,0.00002105633,0.000009304102,0.00003406241,0.00006008695,0.00004596893],"domain_scores_gemma":[0.9998342,0.00001644299,0.00003811012,0.00002430146,0.00002678969,0.00006009548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000987819,0.00003421497,0.0003503766,0.00006108581,0.000005678529,0.00006940828,0.00001960993,0.0001826735,0.9953408,0.0008662568,0.0003578133,0.002613235],"study_design_scores_gemma":[0.0000515312,0.0002118055,0.009361267,0.00002601819,0.00001416838,0.0003066755,0.00006566561,0.003537549,0.9747621,0.0008705528,0.01078623,0.000006534958],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9547855,0.005490966,0.02082278,0.0006405374,0.0003055529,0.00006393763,0.0003754231,0.0006437157,0.01687156],"genre_scores_gemma":[0.9818209,0.0007204803,0.005405187,0.0001039003,0.00008320026,0.00003253179,0.0002394209,0.0001259606,0.01146835],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004680396,"threshold_uncertainty_score":0.01565748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01128742626811263,"score_gpt":0.2210585982645042,"score_spread":0.2097711719963916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}