{"id":"W4286587740","doi":"10.3390/curroncol29080413","title":"An Exceptional Response to Dostarlimab in Mismatch Repair Deficient, Microsatellite Instability-High and Platinum Refractory Endometrial Cancer","year":2022,"lang":"en","type":"article","venue":"Current Oncology","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Microsatellite instability; Endometrial cancer; Medicine; DNA mismatch repair; Immunotherapy; Refractory (planetary science); Oncology; Cancer; Internal medicine; Cancer research; Microsatellite; Genetics; Gene; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003600949,0.0006727512,0.000789099,0.001075035,0.0009409806,0.0007260055,0.0004167,0.002444483,0.0007823589],"category_scores_gemma":[0.002692176,0.0003499562,0.0006122514,0.0004750807,0.0006316602,0.0006011712,0.0007310783,0.001626374,0.0003333732],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004414702,"about_ca_system_score_gemma":0.0003074718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005211942,"about_ca_topic_score_gemma":0.00106016,"domain_scores_codex":[0.9995995,0.00008321404,0.00004824052,0.00008220316,0.0000644187,0.0001223519],"domain_scores_gemma":[0.9988108,0.0004318923,0.0001878325,0.0001129762,0.00006627118,0.0003901718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.0001105996,0.00002356383,0.00652124,0.00003746655,0.00001066685,0.986907,0.00012346,0.0001532361,0.002676117,0.000131066,0.0002748882,0.003030701],"study_design_scores_gemma":[0.00001123943,0.0001322853,0.005669458,0.000009480344,0.0000149681,0.9910341,0.00006609772,0.0004036206,0.001561233,0.0001485682,0.0009389163,0.00001011966],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9749694,0.007086825,0.005106268,0.003662057,0.0004269651,0.0001694777,0.0002568403,0.0002875329,0.008034497],"genre_scores_gemma":[0.996071,0.0009452011,0.001188385,0.0006536866,0.0002712442,0.00001392697,0.00007547718,0.00002422657,0.0007568084],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002444483,"threshold_uncertainty_score":0.003203154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0828811947845958,"score_gpt":0.4072806096103363,"score_spread":0.3243994148257405,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}