{"id":"W4286592247","doi":"10.1161/circulationaha.122.059150","title":"Renal and Vascular Effects of Combined SGLT2 and Angiotensin-Converting Enzyme Inhibition","year":2022,"lang":"en","type":"article","venue":"Circulation","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; Boehringer Ingelheim (Canada); Toronto General Hospital","funders":"","keywords":"Ramipril; Empagliflozin; Medicine; Renal function; Urology; Effective renal plasma flow; Renal blood flow; Internal medicine; Endocrinology; Aliskiren; Tubuloglomerular feedback; Blood pressure; Renin–angiotensin system; Diabetes mellitus; Type 2 diabetes","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002051652,0.001011288,0.002814792,0.0003386726,0.0002535054,0.000775796,0.0004834284,0.000655428,0.002648463],"category_scores_gemma":[0.001196071,0.0005306691,0.001377366,0.000345907,0.0006253097,0.0007051724,0.0004776164,0.001886796,0.0002739431],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003624093,"about_ca_system_score_gemma":0.0006505905,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001736984,"about_ca_topic_score_gemma":0.0006258544,"domain_scores_codex":[0.999076,0.000510827,0.00008892271,0.0001135687,0.00009621029,0.0001143833],"domain_scores_gemma":[0.9988239,0.000379556,0.0003392938,0.00007982417,0.00004235227,0.0003349013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8652819,0.02438419,0.01150527,0.001147226,0.003328908,0.0001659532,0.0001015239,0.0008223893,0.0304764,0.00009866121,0.0003520498,0.06233541],"study_design_scores_gemma":[0.3210683,0.6448631,0.02343714,0.00006714773,0.002113946,0.0003441173,0.00004801771,0.001086475,0.006027741,0.0001022718,0.000814085,0.0000277959],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996418,0.00246218,0.0003178678,0.0001129786,0.00004901466,0.0001699515,0.00009181987,0.00001975563,0.0003583181],"genre_scores_gemma":[0.9967517,0.001062839,0.001106949,0.0001589962,0.0002625582,0.0002655176,0.0001390652,0.000006584755,0.0002458191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002814792,"threshold_uncertainty_score":0.01085031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007226421578070862,"score_gpt":0.2052488472571835,"score_spread":0.1980224256791126,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}