{"id":"W4286629480","doi":"10.21203/rs.3.rs-1800909/v1","title":"Sex differences in the inflammatory response of the mouse DRG and its connection to pain in Multiple Sclerosis ","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"MacEwan University; University of Alberta","funders":"Canadian Institutes of Health Research; Multiple Sclerosis Society; University of Alberta; Multiple Sclerosis Society of Canada; European Genomic Institute for Diabetes","keywords":"Nociceptor; Sensitization; Experimental autoimmune encephalomyelitis; Multiple sclerosis; Medicine; Neuroscience; Sensory system; Inflammation; Dorsal root ganglion; Nociception; Neuropathic pain; Disease; Sensory neuron; Chronic pain; Immunology; Receptor; Biology; Pathology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002288305,0.0002599318,0.0002334733,0.0008718287,0.0001819761,0.0003441051,0.0001985131,0.0004096493,0.002968876],"category_scores_gemma":[0.0002252754,0.0002010504,0.0003566674,0.0003002005,0.0002216206,0.000279376,0.0002386359,0.0006957594,0.000386302],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002378431,"about_ca_system_score_gemma":0.0001135537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004519394,"about_ca_topic_score_gemma":0.0006633214,"domain_scores_codex":[0.9997681,0.0000277626,0.00002180207,0.00007045364,0.00006069088,0.0000512783],"domain_scores_gemma":[0.999678,0.00003462984,0.0001478694,0.00002044315,0.00005467469,0.00006435868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007137944,0.0001267065,0.007448805,0.0001149614,0.00002302509,0.0002207408,0.00009921756,0.00003913895,0.9855762,0.0001633123,0.0001360374,0.005338103],"study_design_scores_gemma":[0.0000646798,0.002657393,0.4621463,0.0001056286,0.0001322194,0.002405157,0.0006606184,0.0006959134,0.5257739,0.0007382612,0.0045677,0.00005205392],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894309,0.004910394,0.001972718,0.0002454834,0.00009118958,0.00002968402,0.001599177,0.00004814849,0.001672268],"genre_scores_gemma":[0.9917107,0.002125185,0.001242117,0.0001852091,0.00002574518,0.0000777656,0.0005406003,0.00002556942,0.004067023],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002968876,"threshold_uncertainty_score":0.009931862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1423724585800835,"score_gpt":0.3641080589120277,"score_spread":0.2217356003319442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}