{"id":"W4286630390","doi":"10.3389/fnagi.2022.859873","title":"Longitudinal Intraindividual Cognitive Variability Is Associated With Reduction in Regional Cerebral Blood Flow Among Alzheimer’s Disease Biomarker-Positive Older Adults","year":2022,"lang":"en","type":"article","venue":"Frontiers in Aging Neuroscience","topic":"Advanced Neuroimaging Techniques and Applications","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Johnson and Johnson Pharmaceutical Research and Development; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; Servier; Eisai; Janssen Alzheimer Immunotherapy Research And Development; Northern California Institute for Research and Education; F. Hoffmann-La Roche; Biogen; BioClinica; Novartis Pharmaceuticals Corporation; Pfizer; Bristol-Myers Squibb; Eli Lilly and Company; Meso Scale Diagnostics; National Institute on Aging; Alzheimer's Association; University of Southern California; H. Lundbeck A/S; U.S. Department of Veterans Affairs; Foundation for the National Institutes of Health","keywords":"Biomarker; Medicine; Cerebral blood flow; Neuropsychology; Dementia; Magnetic resonance imaging; Alzheimer's Disease Neuroimaging Initiative; Cardiology; Internal medicine; Neuroimaging; Cerebrospinal fluid; Cognitive decline; Alzheimer's disease; Oncology; Disease; Psychology; Cognition; Radiology; Psychiatry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007295263,0.0002883617,0.0002970301,0.0005551602,0.0003550347,0.0004286828,0.000267179,0.0004759766,0.0005765453],"category_scores_gemma":[0.002524672,0.0002344566,0.0003078883,0.000433352,0.0001818282,0.0003286667,0.0003507101,0.0005268345,0.0001660534],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001602364,"about_ca_system_score_gemma":0.0001279187,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003386029,"about_ca_topic_score_gemma":0.003923658,"domain_scores_codex":[0.9997261,0.00005851488,0.00003114977,0.00009769259,0.00005095613,0.00003552463],"domain_scores_gemma":[0.9983189,0.0003072628,0.0008622685,0.0001818709,0.0001871433,0.0001425565],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004573407,0.00007317423,0.9942248,0.000009929999,0.0001178478,0.00008484127,0.000184145,0.0000698673,0.001293041,0.00001297616,0.00008475377,0.003387157],"study_design_scores_gemma":[0.000002323611,0.00007337963,0.9996025,0.00000123965,0.00001287982,0.00007065316,0.00002534994,0.0001038832,0.00006144403,0.00001586624,0.00002860807,0.0000018736],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993914,0.0001776279,0.0001131077,0.00001879872,0.000003720118,0.000003656789,0.00008263859,0.000006095198,0.0002028355],"genre_scores_gemma":[0.9996135,0.00004547084,0.00007737389,0.00001447324,0.000006684344,0.00000527358,0.0001185908,0.000001789082,0.0001169586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003386029,"threshold_uncertainty_score":0.006732643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04002928001462359,"score_gpt":0.3003318392567934,"score_spread":0.2603025592421698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}