{"id":"W4286635296","doi":"10.1016/j.jchf.2022.04.015","title":"Sequential Evaluation of NT-proBNP in Heart Failure","year":2022,"lang":"en","type":"article","venue":"JACC Heart Failure","topic":"Heart Failure Treatment and Management","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian VIGOUR Centre; University of Alberta","funders":"Roche Diagnostics; Merck Sharp and Dohme; Servier; MyoKardia; Boston Scientific Corporation; Amgen; Boehringer Ingelheim; Medtronic; Novartis; Bayer; AstraZeneca; National Medical Research Council; Cytokinetics; American Regent; Sanofi; Merck; Vifor Pharma; Bristol-Myers Squibb Foundation","keywords":"Medicine; Internal medicine; Heart failure; Natriuretic peptide; Odds ratio; Randomization; Placebo; Cardiology; Gastroenterology; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001848038,0.0002536908,0.0005648798,0.0004426183,0.0001643233,0.00002072549,0.0001201396,0.0001103687,0.005737651],"category_scores_gemma":[0.0001003719,0.000245787,0.0002348285,0.0007444466,0.00005660133,0.000156055,0.0002041786,0.0004546225,0.0001355191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004751378,"about_ca_system_score_gemma":0.0004556997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002919589,"about_ca_topic_score_gemma":0.0004852204,"domain_scores_codex":[0.9965411,0.0004659017,0.0005528734,0.0004951932,0.001473171,0.0004717163],"domain_scores_gemma":[0.9989173,0.00005207758,0.00009772326,0.0005779063,0.0001962671,0.0001587421],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003388028,0.0013787,0.09895441,0.0002584446,0.0002402438,0.0000622435,0.001184647,0.001161634,0.02808519,0.001343605,0.8644353,0.002556851],"study_design_scores_gemma":[0.006320723,0.0007838452,0.01864658,0.00009631118,0.0003578194,0.000113772,0.002207927,0.001510803,0.003315046,0.0003656911,0.9659863,0.0002952489],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8341959,0.0003425583,0.00002944456,0.1601084,0.0003986056,0.003390392,0.00003443766,0.0001454279,0.001354799],"genre_scores_gemma":[0.9861603,0.000003117035,0.01111771,0.0009927339,0.0001744095,0.0005143236,0.000176575,0.00004177834,0.0008190658],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1591157,"threshold_uncertainty_score":0.9999995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03765822706538563,"score_gpt":0.3163915223184215,"score_spread":0.2787332952530359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}