{"id":"W4286685058","doi":"10.1002/bit.28190","title":"From functional genomics of vero cells to CRISPR‐based genomic deletion for improved viral production rates","year":2022,"lang":"en","type":"article","venue":"Biotechnology and Bioengineering","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Vero cell; Biology; CRISPR; ISG15; Virology; Functional genomics; Gene; Virus; Viral replication; Genetics; Genome; Genomics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007200138,0.0007816073,0.0007196496,0.0005507244,0.0001845317,0.0009776144,0.0005586586,0.0005519831,0.00157764],"category_scores_gemma":[0.0006140519,0.0003299966,0.0007255476,0.0003554208,0.0003465723,0.0003114607,0.0006252275,0.001257961,0.001076748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005202633,"about_ca_system_score_gemma":0.0002890057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000582478,"about_ca_topic_score_gemma":0.0007819188,"domain_scores_codex":[0.9993839,0.0001089784,0.00008078343,0.0001524778,0.0002032666,0.00007054857],"domain_scores_gemma":[0.9997292,0.00008307535,0.00006434902,0.00005124928,0.00004029805,0.00003185729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002568958,0.00001529613,0.00008221224,0.00005988756,0.00001021311,0.00004111707,0.00001736341,0.0005892258,0.9965553,0.0002247074,0.00009437768,0.002284616],"study_design_scores_gemma":[0.00001227151,0.0001798983,0.001281704,0.00002411806,0.00004326623,0.0001826483,0.00003299621,0.007183562,0.9820598,0.0002723623,0.0087027,0.00002452173],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6401503,0.003379376,0.3343088,0.0005810865,0.0004636607,0.000613114,0.006686335,0.004405665,0.00941169],"genre_scores_gemma":[0.8333944,0.002643418,0.145744,0.0002609895,0.0000354153,0.0004662961,0.009574246,0.001028028,0.006853278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00157764,"threshold_uncertainty_score":0.005277753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006331138571204507,"score_gpt":0.2351738186657961,"score_spread":0.2288426800945916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}