{"id":"W4286716083","doi":"10.1038/s41598-022-16896-8","title":"Human iPSC co-culture model to investigate the interaction between microglia and motor neurons","year":2022,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Clarendon Fund; Medical Research Council; Natural Sciences and Engineering Research Council of Canada; Memorial Sloan-Kettering Cancer Center; Memorial University of Newfoundland; University of Oxford; Motor Neurone Disease Association; Parkinson's UK; Eidgenössische Technische Hochschule Zürich; National Institute for Health and Care Research; McGill University; Department of Health and Social Care; Academy of Medical Sciences; Wellcome Trust","keywords":"Amyotrophic lateral sclerosis; Microglia; Motor neuron; Neuroscience; Neuron; Biology; Crosstalk; Medicine; Disease; Spinal cord; Pathology; Immunology; Inflammation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005625421,0.0006119022,0.0007243524,0.0005765057,0.0003986048,0.0005126348,0.0006171336,0.0009925739,0.003449591],"category_scores_gemma":[0.0002030923,0.0001834057,0.0004938841,0.0003825883,0.0003419314,0.0003798916,0.0005213075,0.001595772,0.001618494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003482176,"about_ca_system_score_gemma":0.000525976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008435666,"about_ca_topic_score_gemma":0.001102682,"domain_scores_codex":[0.9994212,0.00005703688,0.00006586809,0.0001480326,0.0002287826,0.00007913796],"domain_scores_gemma":[0.9998294,0.00002693155,0.00002948547,0.00003769189,0.00004487601,0.00003156675],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005886491,0.0006075579,0.00111593,0.0005218663,0.00006914666,0.001316081,0.0002498973,0.001094912,0.9812346,0.002011678,0.002001294,0.009188416],"study_design_scores_gemma":[0.0001041219,0.001567852,0.004880374,0.0001875265,0.0002995931,0.003474943,0.0002248319,0.006801389,0.9288445,0.0009335314,0.05264432,0.0000370936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8329476,0.01791532,0.1039902,0.0009690178,0.001672367,0.00184913,0.008249846,0.0008942346,0.03151241],"genre_scores_gemma":[0.939791,0.007929334,0.03013302,0.000582683,0.0002395347,0.002323497,0.005646682,0.00008380359,0.01327047],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003449591,"threshold_uncertainty_score":0.01154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06274554407303236,"score_gpt":0.3031277665348397,"score_spread":0.2403822224618073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}