{"id":"W4286797697","doi":"10.1093/nar/gkac620","title":"Zinc controls PML nuclear body formation through regulation of a paralog specific auto-inhibition in SUMO1","year":2022,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Division of Materials Research; National Research Council Canada; National Institute of General Medical Sciences; Western Economic Diversification Canada; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Hokkaido University; National Science Foundation; National Institutes of Health; University of Saskatchewan; Canadian Light Source","keywords":"Biology; Death-associated protein 6; Zinc finger; Promyelocytic leukemia protein; Cell biology; Nuclear protein; Function (biology); Plasma protein binding; Genetics; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001054242,0.0002304782,0.0001766654,0.000159679,0.0002191675,0.0003663067,0.0002865094,0.0001482819,0.0008653298],"category_scores_gemma":[0.0001234142,0.0001432265,0.0001561172,0.0001005276,0.0002824307,0.0001520797,0.0002491893,0.0002839716,0.0003775769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005377831,"about_ca_system_score_gemma":0.0002156346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009909628,"about_ca_topic_score_gemma":0.002286037,"domain_scores_codex":[0.9998899,0.0000152712,0.000009185794,0.0000339009,0.00002749684,0.00002428782],"domain_scores_gemma":[0.9998721,0.00001187128,0.00004805084,0.00001641528,0.00001499265,0.00003651822],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008218649,0.00001002925,0.0001958596,0.000008331494,0.000001312832,0.00003157802,0.000008939992,0.00003598319,0.9990633,0.0001053082,0.00001268583,0.00044446],"study_design_scores_gemma":[0.00001441414,0.0000705208,0.005621728,0.000002229492,0.00000489885,0.000119075,0.00002062861,0.0009553383,0.9919417,0.00009534578,0.001151553,0.00000265118],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961423,0.0006440652,0.002014791,0.00005681273,0.00001231475,0.000006742771,0.0001660944,0.00009547846,0.0008614231],"genre_scores_gemma":[0.9967555,0.0002695997,0.0006914714,0.00001473426,0.000002904088,0.000006044159,0.0001239025,0.00001635363,0.00211956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009909628,"threshold_uncertainty_score":0.003901899,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04331831429243341,"score_gpt":0.3115275391219414,"score_spread":0.268209224829508,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}