{"id":"W4286856618","doi":"10.3791/4266-v","title":"Iterative Optimization of DNA Duplexes for Crystallization of SeqA-DNA Complexes","year":2012,"lang":"en","type":"article","venue":"Journal of Visualized Experiments","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"SeqA protein domain; DNA; Biology; DNA replication; HMG-box; DNA-binding protein; Genetics; Cell biology; Origin of replication; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001341881,0.001417337,0.002007991,0.0008267869,0.000670554,0.001070666,0.00159723,0.0008572041,0.004157819],"category_scores_gemma":[0.00322424,0.001144801,0.0005978933,0.001571303,0.0004625664,0.0009250939,0.001171655,0.002086302,0.002147541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001778127,"about_ca_system_score_gemma":0.001418282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002187948,"about_ca_topic_score_gemma":0.005018177,"domain_scores_codex":[0.9989439,0.0002051416,0.0001266964,0.0002699374,0.0003298217,0.0001244817],"domain_scores_gemma":[0.9991763,0.0003651925,0.00006782565,0.00008015309,0.0001817419,0.0001287419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008959153,0.000837234,0.0009923576,0.001156666,0.0001775992,0.0005752984,0.0007621946,0.04685959,0.9194643,0.005244923,0.002442115,0.02059167],"study_design_scores_gemma":[0.0005221405,0.001201571,0.0009201047,0.0001117517,0.0001502104,0.0002766818,0.0003985602,0.1647057,0.8025446,0.002056556,0.0269854,0.0001266378],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.8252676,0.006571115,0.1499744,0.0008784972,0.0003718211,0.001801375,0.002516988,0.002066475,0.01055181],"genre_scores_gemma":[0.7914724,0.005695156,0.1883154,0.000280163,0.00005620451,0.003023743,0.004091032,0.001299405,0.005766448],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.004157819,"threshold_uncertainty_score":0.01390928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02841635540441468,"score_gpt":0.3872863409024601,"score_spread":0.3588699854980454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}