{"id":"W4287098948","doi":"10.2139/ssrn.4166327","title":"The <i>CIt</i> Protocol: A Blueprint to Potentiate the Immunogenicity of Immunoproteasome-Reprogrammed Mesenchymal Stromal Cells","year":2022,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Centre Hospitalier Universitaire Sainte-Justine; Université du Québec à Montréal; Université de Montréal","funders":"","keywords":"Mesenchymal stem cell; Immunogenicity; Chemistry; Stromal cell; Cell biology; Cancer research; Biology; Immunology; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002191694,0.00359179,0.002300587,0.002957138,0.002241988,0.001344799,0.002610377,0.001697596,0.1252426],"category_scores_gemma":[0.001952458,0.002500004,0.001928556,0.002251422,0.001717733,0.001222044,0.001826433,0.006792379,0.1040418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009291902,"about_ca_system_score_gemma":0.002479753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009423291,"about_ca_topic_score_gemma":0.003339326,"domain_scores_codex":[0.99763,0.0004923589,0.0003175423,0.0004215976,0.0006573468,0.0004812159],"domain_scores_gemma":[0.9979163,0.0005237258,0.0001366478,0.0008239571,0.0003796274,0.000219779],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007901757,0.0002767307,0.0001457153,0.001102742,0.00004452661,0.0005454737,0.0003225691,0.0003182764,0.9206206,0.006371021,0.04475455,0.02470767],"study_design_scores_gemma":[0.0003061092,0.0004344464,0.001853973,0.000243388,0.00008572525,0.0007240863,0.0000689354,0.001391612,0.6155157,0.001599691,0.377629,0.0001473661],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.04500152,0.004782255,0.7326367,0.003886146,0.007369368,0.02784056,0.04872649,0.02684271,0.1029142],"genre_scores_gemma":[0.06926692,0.009250649,0.4740779,0.002409802,0.00100848,0.06051659,0.07587262,0.01240577,0.2951913],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.1252426,"threshold_uncertainty_score":0.4189782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005441547727344845,"score_gpt":0.2310953962848155,"score_spread":0.2256538485574706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}