{"id":"W4287377570","doi":"10.1111/pcmr.13058","title":"Landscape of mutations in early stage primary cutaneous melanoma: An <scp>InterMEL</scp> study","year":2022,"lang":"en","type":"article","venue":"Pigment Cell & Melanoma Research","topic":"Cutaneous Melanoma Detection and Management","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"National Center for Advancing Translational Sciences; Memorial Sloan-Kettering Cancer Center; National Institute of Environmental Health Sciences; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill; National Institute of General Medical Sciences; National Health and Medical Research Council; University of Texas MD Anderson Cancer Center; Roswell Park Alliance Foundation, Roswell Park Cancer Institute; Char and Chuck Fowler Family Foundation; National Cancer Institute; National Institutes of Health; Cleveland Foundation","keywords":"Neuroblastoma RAS viral oncogene homolog; CDKN2A; Melanoma; Perineural invasion; GNAQ; Cancer research; Medicine; Stage (stratigraphy); Pathology; Biology; Mutation; KRAS; Internal medicine; Cancer; Gene; Genetics; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001859209,0.0002850813,0.000576779,0.001479724,0.0003989142,0.0000751293,0.0005098917,0.00007690334,0.001382694],"category_scores_gemma":[0.0001088184,0.000289396,0.0001386397,0.001195758,0.0001260975,0.0001126931,0.0007244056,0.001064625,0.0001181502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006365046,"about_ca_system_score_gemma":0.0002720271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000929065,"about_ca_topic_score_gemma":0.0003606211,"domain_scores_codex":[0.9945678,0.000965106,0.000750261,0.000790474,0.00208476,0.000841652],"domain_scores_gemma":[0.9978727,0.0004765146,0.0001730194,0.0009312965,0.0002115559,0.0003349199],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002965569,0.03752194,0.7844986,0.001389432,0.000732443,0.02619149,0.05065551,0.001916112,0.07173905,0.0004441884,0.006889165,0.01505648],"study_design_scores_gemma":[0.02360479,0.06536503,0.5657321,0.0001446762,0.0004931911,0.001754775,0.2388617,0.004184824,0.02284419,0.000310245,0.07590336,0.0008010667],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9506602,0.0002336037,0.00002214823,0.0001152517,0.0002619841,0.002858222,0.0000576418,0.00009164825,0.04569929],"genre_scores_gemma":[0.9685593,0.00004526351,0.0001282673,0.0000627544,0.00009575898,0.000584289,0.0001344192,0.00007042048,0.03031954],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2187665,"threshold_uncertainty_score":0.9999558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0368253793998226,"score_gpt":0.3196187771049465,"score_spread":0.2827933977051239,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}