{"id":"W4287377570","doi":"10.1111/pcmr.13058","title":"Landscape of mutations in early stage primary cutaneous melanoma: An <scp>InterMEL</scp> study","year":2022,"lang":"en","type":"article","venue":"Pigment Cell & Melanoma Research","topic":"Cutaneous Melanoma Detection and Management","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"National Center for Advancing Translational Sciences; Memorial Sloan-Kettering Cancer Center; National Institute of Environmental Health Sciences; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill; National Institute of General Medical Sciences; National Health and Medical Research Council; University of Texas MD Anderson Cancer Center; Roswell Park Alliance Foundation, Roswell Park Cancer Institute; Char and Chuck Fowler Family Foundation; National Cancer Institute; National Institutes of Health; Cleveland Foundation","keywords":"Neuroblastoma RAS viral oncogene homolog; CDKN2A; Melanoma; Perineural invasion; GNAQ; Cancer research; Medicine; Stage (stratigraphy); Pathology; Biology; Mutation; KRAS; Internal medicine; Cancer; Gene; Genetics; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003565832,0.0001451675,0.0002217893,0.0008043832,0.0002986638,0.0006022921,0.0002206283,0.0002943697,0.002966666],"category_scores_gemma":[0.0006130645,0.0001073141,0.0002503018,0.0008024911,0.0001726823,0.0003127747,0.0002617615,0.0002941096,0.0005087464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002653833,"about_ca_system_score_gemma":0.000211767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001177269,"about_ca_topic_score_gemma":0.001678489,"domain_scores_codex":[0.9998666,0.00002329176,0.00001142876,0.00004164174,0.00003090702,0.00002613875],"domain_scores_gemma":[0.9994937,0.00009455834,0.0001589446,0.00004807427,0.000105662,0.000099009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001516444,0.0001863982,0.9058197,0.0002461197,0.0002137914,0.003424935,0.0002380254,0.0003118138,0.03446684,0.0003121138,0.001917043,0.05134681],"study_design_scores_gemma":[0.00001679537,0.0003783476,0.9883937,0.00003847999,0.00009433889,0.005366108,0.0002385699,0.0004370765,0.001834999,0.0001846511,0.003009702,0.000007183303],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955096,0.001700984,0.0002248249,0.0001107665,0.000005344994,0.00001875394,0.000804345,0.00001189408,0.001613454],"genre_scores_gemma":[0.9976965,0.0005770474,0.000238076,0.0001157264,0.00001525829,0.0000112004,0.0008278718,0.000009705217,0.0005086395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002966666,"threshold_uncertainty_score":0.009924531,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0368253793998226,"score_gpt":0.3196187771049465,"score_spread":0.2827933977051239,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}