{"id":"W4287378024","doi":"10.1093/braincomms/fcac193","title":"Causal links among amyloid, tau, and neurodegeneration","year":2022,"lang":"en","type":"article","venue":"Brain Communications","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; Takeda Pharmaceutical Company; IXICO; H. Lundbeck A/S; Servier; Northern California Institute for Research and Education; Eisai Incorporated; DoD Alzheimer's Disease Neuroimaging Initiative; BioClinica; Biogen; Pfizer; Novartis Pharmaceuticals Corporation; Roche; University of Southern California; U.S. Department of Defense; Eli Lilly and Company; GE Healthcare; Merck; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Neurodegeneration; Entorhinal cortex; Neuroscience; Alzheimer's Disease Neuroimaging Initiative; Tauopathy; Temporal lobe; Psychology; Neuroimaging; Temporal cortex; Dementia; Amyloid (mycology); Neocortex; Alzheimer's disease; Medicine; Hippocampus; Disease; Internal medicine; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007751016,0.0006960595,0.0004851533,0.0009710094,0.0006202597,0.001020076,0.0009796013,0.0006380645,0.005601579],"category_scores_gemma":[0.02754584,0.0004711192,0.001083063,0.0009153206,0.001050824,0.001000788,0.001822319,0.001134265,0.0001656196],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005382282,"about_ca_system_score_gemma":0.001049831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006025626,"about_ca_topic_score_gemma":0.005094341,"domain_scores_codex":[0.9953988,0.002957558,0.0001589817,0.0007438016,0.0003680916,0.0003727716],"domain_scores_gemma":[0.9768237,0.01609232,0.003514771,0.00186168,0.001012179,0.000695308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00161827,0.0004363369,0.9714607,0.000293663,0.003049124,0.0005496442,0.0007716751,0.0008928564,0.002259425,0.004454619,0.0009003579,0.01331331],"study_design_scores_gemma":[0.000201771,0.0004804764,0.9615409,0.0001532014,0.002693973,0.0005815868,0.0009042247,0.005229467,0.002212624,0.02399459,0.001964465,0.00004272088],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833551,0.00383623,0.007528881,0.001613599,0.0001155299,0.00009636731,0.001032571,0.00006746154,0.002354226],"genre_scores_gemma":[0.9979396,0.0002749997,0.001205903,0.00009912145,0.0000393369,0.00005935403,0.0001527568,0.000005669396,0.0002232178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007751016,"threshold_uncertainty_score":0.04099178,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03554375990609267,"score_gpt":0.3311691933053319,"score_spread":0.2956254333992392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}