{"id":"W4287378024","doi":"10.1093/braincomms/fcac193","title":"Causal links among amyloid, tau, and neurodegeneration","year":2022,"lang":"en","type":"article","venue":"Brain Communications","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; Takeda Pharmaceutical Company; IXICO; H. Lundbeck A/S; Servier; Northern California Institute for Research and Education; Eisai Incorporated; DoD Alzheimer's Disease Neuroimaging Initiative; BioClinica; Biogen; Pfizer; Novartis Pharmaceuticals Corporation; Roche; University of Southern California; U.S. Department of Defense; Eli Lilly and Company; GE Healthcare; Merck; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Neurodegeneration; Entorhinal cortex; Neuroscience; Alzheimer's Disease Neuroimaging Initiative; Tauopathy; Temporal lobe; Psychology; Neuroimaging; Temporal cortex; Dementia; Amyloid (mycology); Neocortex; Alzheimer's disease; Medicine; Hippocampus; Disease; Internal medicine; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003808285,0.00006196403,0.00008464977,0.0001029792,0.0006757678,0.00003702049,0.0002024395,0.00002904924,0.0004606825],"category_scores_gemma":[0.0001426863,0.00006547066,0.00003071301,0.0002131964,0.0001500699,0.00007196998,0.0006197251,0.0005069269,0.0000119434],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005404223,"about_ca_system_score_gemma":0.00007473675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001194467,"about_ca_topic_score_gemma":0.0001275584,"domain_scores_codex":[0.999072,0.0002917343,0.0001364028,0.000139076,0.0002249823,0.0001358293],"domain_scores_gemma":[0.9989273,0.0001853892,0.00003561437,0.0006844489,0.00008143262,0.00008582576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00011501,0.00138975,0.799834,0.00005114633,0.0001525253,0.00002282866,0.001311833,0.0000221102,0.02647994,0.01252779,0.08488543,0.07320764],"study_design_scores_gemma":[0.001334135,0.0004676291,0.8249073,0.00001224174,0.00005890995,0.00006913427,0.0007258581,0.00412804,0.0006280525,0.0004993592,0.1670379,0.000131463],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9267212,0.0005230912,0.0004246335,0.05259822,0.00004094288,0.0005626516,0.00002217792,0.00006579429,0.01904136],"genre_scores_gemma":[0.9900236,0.000116333,0.00045698,0.002700804,0.00002992087,0.0002906281,0.0003099667,0.0000126375,0.00605911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08215243,"threshold_uncertainty_score":0.5197528,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03554375990609267,"score_gpt":0.3311691933053319,"score_spread":0.2956254333992392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}