{"id":"W4287509805","doi":"10.1038/s41591-022-01902-3","title":"Genetic risk score enhances the risk prediction of severe obesity in adult survivors of childhood cancer","year":2022,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Childhood Cancer Survivors' Quality of Life","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Cancer Institute; U.S. Department of Health and Human Services","keywords":"Obesity; Medicine; Childhood cancer; Childhood obesity; Risk assessment; Environmental health; Internal medicine; Cancer; Oncology; Demography; Overweight; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity"],"consensus_categories":[],"category_scores_codex":[0.001904814,0.0002886534,0.0009043438,0.0002893228,0.000197695,0.000002508761,0.0004120006,0.0002307622,0.0005734148],"category_scores_gemma":[0.001660702,0.0001976011,0.0001696356,0.001236318,0.0003731885,0.00005545767,0.0001547587,0.002508632,0.000001146421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001903384,"about_ca_system_score_gemma":0.0003501536,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02630821,"about_ca_topic_score_gemma":0.01361226,"domain_scores_codex":[0.9956995,0.0007497541,0.001044323,0.0004971619,0.001682006,0.000327309],"domain_scores_gemma":[0.9972636,0.0005506655,0.0009790588,0.0007592466,0.0003201,0.0001273843],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004724717,0.0005276267,0.9766969,0.0003807105,0.000272276,0.00001052756,0.01310628,0.0005606822,0.0008753928,0.00008761241,0.00250805,0.004501453],"study_design_scores_gemma":[0.003734485,0.0009997914,0.9859577,0.0007420514,0.0004914973,0.00004224657,0.003956947,0.0001794756,0.002038431,0.0004844384,0.001227093,0.0001458258],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9764211,0.01602164,0.0000365368,0.00400268,0.00140909,0.001008459,0.000662317,0.00004729484,0.0003909199],"genre_scores_gemma":[0.9929641,0.004620761,0.000123289,0.001180629,0.0008247464,0.00009531889,0.00006014107,0.00003621032,0.00009477122],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01654307,"threshold_uncertainty_score":0.9997926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008954911277391408,"score_gpt":0.2708091197299169,"score_spread":0.2618542084525255,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}