{"id":"W4287510478","doi":"10.1038/s41567-022-01676-y","title":"Membrane ruffling is a mechanosensor of extracellular fluid viscosity","year":2022,"lang":"en","type":"article","venue":"Nature Physics","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":85,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute of General Medical Sciences; National Institute on Aging; Natural Sciences and Engineering Research Council of Canada; National Science Foundation; Canadian Institutes of Health Research; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; National Cancer Institute; National Institutes of Health; U.S. Department of Health and Human Services; Government of Canada; Air Force Office of Scientific Research; National Heart, Lung, and Blood Institute; U.S. Department of Defense","keywords":"Membrane ruffling; Lamellipodium; Viscosity; Extracellular; Biophysics; Cell biology; Motility; Adhesion; Membrane; Cell adhesion; Focal adhesion; Cell membrane; Cell; Cell migration; Chemistry; Cytoskeleton; Materials science; Biology; Biochemistry; Composite material","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002931464,0.0002749415,0.0004545877,0.0003912693,0.0005807943,0.001315077,0.0005288044,0.0008496476,0.001287193],"category_scores_gemma":[0.0008714607,0.0003081996,0.0002912317,0.0003119046,0.0005560139,0.001234966,0.0006693109,0.0009690131,0.0003956531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000389934,"about_ca_system_score_gemma":0.0001561749,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003520952,"about_ca_topic_score_gemma":0.0002179262,"domain_scores_codex":[0.999673,0.00003364181,0.00001786352,0.00008785978,0.0001007001,0.00008687213],"domain_scores_gemma":[0.9994942,0.0001361324,0.0001718652,0.00004639974,0.000062206,0.00008922417],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001135139,0.00001376679,0.0003729075,0.00004096175,0.000006944011,0.000160933,0.0000272559,0.0001174797,0.9951142,0.001696427,0.0001218367,0.002213733],"study_design_scores_gemma":[0.00003118847,0.0001664236,0.01484209,0.00001547945,0.00002900002,0.001214695,0.0001215757,0.006971415,0.9701484,0.003140828,0.003261935,0.00005696651],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9683579,0.004433651,0.02166241,0.001254178,0.0002595402,0.00002731594,0.0002164345,0.0002767242,0.003511996],"genre_scores_gemma":[0.9955961,0.0007831009,0.001957706,0.0001242006,0.00006569939,0.0000106275,0.0001053958,0.00002496078,0.001332162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001315077,"threshold_uncertainty_score":0.004306078,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006754784276288598,"score_gpt":0.2401035569872891,"score_spread":0.2333487727110005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}