{"id":"W4287701347","doi":"","title":"IL-6 −572C>G and CARD8 304T>A Genetic Polymorphisms are Associated with the Absolute Neutrophil Count in Patients with Hematological Malignancies Under Chemotherapy: An Application of Multilevel Models to a Preliminary Pharmacogenetic Study","year":2020,"lang":"en","type":"article","venue":"DOAJ (DOAJ: Directory of Open Access Journals)","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Absolute neutrophil count; Medicine; Internal medicine; Chemotherapy; Immunology; Gastroenterology; Oncology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006248494,0.001163585,0.00168333,0.000724417,0.0006083043,0.001728162,0.00187177,0.001138555,0.005510534],"category_scores_gemma":[0.0108603,0.000536199,0.004525651,0.0009418862,0.0005186783,0.0005537547,0.0015483,0.002264309,0.0004137148],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005205187,"about_ca_system_score_gemma":0.00103419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01144124,"about_ca_topic_score_gemma":0.006566965,"domain_scores_codex":[0.9949442,0.003399855,0.0001862185,0.0009518494,0.0002031208,0.0003147031],"domain_scores_gemma":[0.9868145,0.009847771,0.001404241,0.001086254,0.00036716,0.0004800592],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005692535,0.0006076883,0.9488266,0.0001815223,0.009850749,0.0004682462,0.000507829,0.01281194,0.0009641456,0.002479666,0.001405958,0.01620315],"study_design_scores_gemma":[0.0009358112,0.002649403,0.6131196,0.0002680865,0.01111685,0.0007154356,0.0009476151,0.3564065,0.0007746961,0.01014719,0.002786351,0.0001324941],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833784,0.001239716,0.01173369,0.0008760944,0.0001063565,0.0001122518,0.001698923,0.00005017817,0.0008044494],"genre_scores_gemma":[0.9935285,0.0002351891,0.004013735,0.00008736698,0.00005969416,0.0001307975,0.001079097,0.0000215793,0.0008439681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01144124,"threshold_uncertainty_score":0.03304559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1748808975201705,"score_gpt":0.4450343997061106,"score_spread":0.2701535021859401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}