{"id":"W4287734271","doi":"10.1016/j.bbadis.2022.166507","title":"Exogenous ketone ester administration attenuates systemic inflammation and reduces organ damage in a lipopolysaccharide model of sepsis","year":2022,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","topic":"Diet and metabolism studies","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Japan Society for the Promotion of Science; Canadian Institutes of Health Research; Alberta Innovates; Heart and Stroke Foundation of Canada","keywords":"Sepsis; Inflammation; Organ dysfunction; Medicine; Ketone bodies; Systemic inflammation; Lipopolysaccharide; Systemic administration; Kidney; Pharmacology; Immunology; Internal medicine; Metabolism; Biology; In vivo","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003136682,0.0009219021,0.0009144302,0.0004767292,0.0003091926,0.0004726271,0.0004359924,0.0005185883,0.001861393],"category_scores_gemma":[0.0004089128,0.0002820959,0.0003167064,0.0003454043,0.000900267,0.0006582259,0.0002817425,0.001886273,0.0003610219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002445266,"about_ca_system_score_gemma":0.0006783647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006058704,"about_ca_topic_score_gemma":0.0008704018,"domain_scores_codex":[0.9998124,0.00004637067,0.0000261732,0.00002455755,0.00002838653,0.0000620537],"domain_scores_gemma":[0.9995288,0.00004339533,0.00009883096,0.00005778211,0.00003673268,0.0002345835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.03690759,0.002043969,0.0004707481,0.0002072823,0.00005268107,0.0002790336,0.00007778077,0.0002517769,0.9525948,0.0001942378,0.0002283175,0.006691841],"study_design_scores_gemma":[0.001780344,0.01731002,0.008756584,0.00004677953,0.0001639501,0.0003560231,0.0002696879,0.001398708,0.9679506,0.000262334,0.001656234,0.00004871725],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997014,0.0009696725,0.0009345245,0.0002171937,0.0001323899,0.00002530809,0.0001801118,0.000073872,0.0004529755],"genre_scores_gemma":[0.9944105,0.00135894,0.001392974,0.0001117735,0.00007672694,0.0000789503,0.0004278253,0.00002834526,0.002113971],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001861393,"threshold_uncertainty_score":0.006226957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01368914291457743,"score_gpt":0.2575676289052563,"score_spread":0.2438784859906788,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}