{"id":"W4287832766","doi":"10.3791/64237","title":"Quantification of Immunostained Caspase-9 in Retinal Tissue","year":2022,"lang":"en","type":"article","venue":"Journal of Visualized Experiments","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Columbia College","funders":"National Institute of Neurological Disorders and Stroke; National Eye Institute","keywords":"Caspase; Biology; Proteases; Programmed cell death; Apoptosis; Cell biology; Neuroscience; Intrinsic apoptosis; Caspase 2; Cell; Computational biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003907983,0.00006554459,0.0001418365,0.0001036313,0.00004580226,0.000005567025,0.0001183814,0.00003777597,0.0001132119],"category_scores_gemma":[0.00002580604,0.00006283035,0.00006255931,0.00009636293,0.00001675843,0.000004284454,0.00006303246,0.00006667146,4.721712e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003591584,"about_ca_system_score_gemma":0.00005693471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002119695,"about_ca_topic_score_gemma":8.895579e-7,"domain_scores_codex":[0.9990685,0.0001228948,0.0004111842,0.00009262698,0.0002161951,0.00008858477],"domain_scores_gemma":[0.9993812,0.000005341417,0.00038514,0.0001206925,0.00008036004,0.00002728861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005555049,0.0002168146,0.0001778183,0.000006221813,0.00002161739,0.000008472634,0.0002572467,0.0002727898,0.9971353,0.0002040268,0.0002114762,0.0009326801],"study_design_scores_gemma":[0.00138567,0.0008549137,0.001021412,0.00001131556,0.000008083566,0.00005148673,0.0007489974,0.00009896294,0.9862826,0.00006620101,0.009402367,0.0000680256],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949954,0.001910809,0.002601332,0.00004070219,0.0002497793,0.0001015837,0.000003740724,0.000001163666,0.00009546629],"genre_scores_gemma":[0.9985501,0.000112369,0.0009380148,0.0000230963,0.00005067408,0.000006647745,0.00003397344,0.0000100228,0.000275147],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01085277,"threshold_uncertainty_score":0.2562147,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02041697923705129,"score_gpt":0.3929214974463321,"score_spread":0.3725045182092808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}