{"id":"W4287834768","doi":"10.1146/annurev-genet-080320-025104","title":"Gametogenesis: Exploring an Endogenous Rejuvenation Program to Understand Cellular Aging and Quality Control","year":2022,"lang":"en","type":"review","venue":"Annual Review of Genetics","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Fondation pour la Recherche Médicale; National Institute on Aging; National Institutes of Health; Glenn Foundation for Medical Research","keywords":"Gametogenesis; Biology; Cell biology; Genetics; Context (archaeology); Meiosis; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001495303,0.0005845377,0.001680077,0.0001415455,0.0001634596,0.00004184226,0.0006052391,0.0002239994,0.00004107277],"category_scores_gemma":[0.0002860668,0.0005822341,0.0004294255,0.0002807135,0.000105618,0.000009459769,0.0003014864,0.0002417493,0.000005114442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007054557,"about_ca_system_score_gemma":0.0003142089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002763689,"about_ca_topic_score_gemma":0.0000178144,"domain_scores_codex":[0.9959975,0.0008703927,0.001229163,0.0009341656,0.0005037811,0.0004650225],"domain_scores_gemma":[0.9976392,0.00007255495,0.0006636318,0.001107596,0.0002295492,0.0002874494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000007842857,0.0001621549,0.000009521004,0.05052211,0.0002380908,0.000005773775,0.0005031609,0.00002313449,0.0007194552,0.00002705555,0.0001316216,0.9476501],"study_design_scores_gemma":[0.0002301434,0.0009691757,0.000005470779,0.005596617,0.001066569,0.00003284882,0.0004116251,0.000003557528,0.0008575311,0.0000100734,0.9901724,0.0006440014],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007314236,0.9941128,0.001913823,0.00004077537,0.0002684156,0.002464591,0.0003428307,0.00002855077,0.00009675765],"genre_scores_gemma":[0.0009400513,0.995267,0.001941434,0.0004729888,0.0002341603,0.0003654528,0.0005917472,0.0001263046,0.00006083104],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9900408,"threshold_uncertainty_score":0.9996629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.163645839138145,"score_gpt":0.3659861836690717,"score_spread":0.2023403445309267,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}